FEN1

(redirected from flap endonuclease 1)

FEN1

A gene on chromosome 11q12 that encodes a protein belonging to the XPG/RAD2 endonuclease family, which removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging-strand DNA synthesis. Direct physical interaction between FEN1 and AP endonuclease 1 during long-patch base excision repair provides co-ordinated loading of the proteins onto the substrate, passing the substrate from one enzyme to another.
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Hamdan, and his team, have published a groundbreaking paper on the mechanism of flap endonuclease 1 (FEN1), in Cell Reports journal.