fixed-dose combination drugs

fixed-dose combination drugs

commercially available drug preparations containing several remedies. Veterinary therapeutic supply lists contain many examples of combinations of antibiotics. These preparations contain their drugs in fixed combinations and therefore have some advantages and some disadvantages. The advantages are that a broad spectrum of antibiotic activity can be achieved, an important feature in veterinary work because so many infections are mixed ones, and the possibility of resistant bacterial populations emerging is reduced.
One disadvantage is that the drugs in the combination may be antagonistic. The antibiotics most likely to demonstrate this activity are the tetracyclines, the macrolides and chloramphenicol. The principal disadvantage is that the dose rate of each of the component drugs is dictated by the content of the other drugs present, a serious matter if the causative bacteria and its sensitivity are known.
References in periodicals archive ?
The initial growth will be due to the increased penetration of fixed-dose combination drugs (Amturnide, Exforge Tribenzor, Azor, Tekturna HCT, Edarbyclor, Twynsta, Benicar HCT, Micardis Plus, Tekamlo, Valturna), a rise in the prevalence population from 181 million to 190 million at a CAGR of 0.
While HCTZ is part of several fixed-dose combination drugs, chlorthalidone is available in only three combination products: clonidine (Clorpres), reserpine (Regroton), and atenolol (Tenoretic), Dr.
com/research/cnk25v/hivaids) has announced the addition of the "HIV/AIDS Therapeutics Market to 2018 - Despite Major Patent Expiries, Increased Uptake of Once-a-Day Fixed-dose Combination Drugs to Drive Growth" report to their offering.
s new report "Pricing and Reimbursement of Fixed-Dose Combination Drugs in the United States" to their offering.
com/reports/c92368) has announced the addition of "The Global Market for Fixed-Dose Combination Drugs for Leading Diseases" to their offering.
The Global Market for Fixed-Dose Combination Drugs for Leading Diseases" analyzes products and applications of fixed-dose combination drugs utilized in the treatment of cardiovascular diseases (hypercholesterolemia and hypertension), diabetes, infectious diseases (bacterial infections, Helicobacter pylori, acquired immune deficiency syndrome--AIDS, HIV infection and tuberculosis), psychiatric disorders (depression and Alzheimer's disease) and respiratory diseases (asthma and chronic obstructive pulmonary disease--COPD).
The Disadvantages Of Fixed-Dose Combination Drugs 9
Regulations Relating To Fixed-Dose Combination Drugs 10
Incentives And Barriers To The Development Of Fixed-Dose Combination Drugs 11
The Challenges Of Manufacturing Fixed-Dose Combination Drugs 11
Potential Fixed-Dose Combination Drugs Lead The Market 98
While the cholesterol management market remains dominated by statins and fixed-dose combination drugs containing statins, the market for drugs to treat hypertension covers a number of classes, such as beta blockers, ACE inhibitors, angiotensin-II receptor antagonists, calcium channel blockers and alpha blockers.