fixed drug reaction

fixed drug reaction

Dermatology  An idiopathic skin eruption more common in blacks, which often recurs at the same place, every time a particular drug or a related congener is administered; FDRs may also occur with chemically unrelated drugs or disappear with repeated administration of the same drug Clinical Sharply circumscribed edematous red-brown or purplish plaque that may be surmounted by a bulla, most often located on the extremities, the hands, and glans penis which with time, becomes lichenified, scaly, ±accompanied by hypermelanosis Agents causing FDR phenazone, barbiturates, sulfonamides, quinine, tetracycline, oxyphenbutazone, chlordiazepoxide, food dyes, toothpaste, mothballs
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Direct systemic effects include fixed drug reaction and pruritus (6).
The differential diagnosis included Behcet's disease, cicatricial pemphigoid, a fixed drug reaction, and allergic contact dermatitis.
Fixed drug reactions have been reported for indomethacin, aspirin, mefenamic acid, diclofenac, piroxicam and paracetamol.

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