fixed drug eruption


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Related to fixed drug eruption: erythema multiforme

fixed drug e·rup·tion

a type of drug eruption that recurs at the same site (or sites) following the administration of a particular drug; the lesions usually consist of intensely erythematous and purplish, sharply demarcated macules, and occasionally of herpetic vesicles; the affected areas undergo gradual involution, but flare and enlarge on readministration of the offending drug and may become hyperpigmented.

fixed drug eruption

well-defined red to purple lesions that appear at the same sites on the skin and mucous membranes each time a particular drug is used. The reaction occurs most commonly in patients who are using tetracycline or phenolphthalein.
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Fixed drug eruption

fix·ed drug e·rup·tion

(fikst drŭg ĕr-ŭp'shŭn)
A type of drug eruption that recurs at a fixed site (or sites) after administration of a particular drug.

fixed drug eruption

A localized red rash with a sharp border, which follows exposure to a drug. The rash usually burns, occurs on the face or the genitals, and, if the offending agent is given again, recurs in the same location.
See also: eruption
References in periodicals archive ?
In vivo dynamics of intraepidermal CD8+T cells and CD4+T cells during the evolution of fixed drug eruption.
Fixed drug eruptions (FDE) are a distinct type of drug eruptions that appear as pruritic, well circumscribed, round or oval-shaped, erythematous macules or edematous plaques, and characteristically recur at the same sites upon re-exposure to the offending drug.
Table 1: Distribution of cases in relation to age and gender Age in Years Males Females Total <9 4 3 7 10-19 7 5 12 20-29 8 9 17 30-39 11 12 23 40-49 10 8 18 50 & Above 5 4 9 Total 45 41 86 Table 2: Drugs causing fixed drug eruptions Drugs No.
The most common pattern of cutaneous ADR observed was fixed drug eruption (54.
Drug eruptions, Stevens-Johnson syndrome, erythema multiforme, fixed drug eruption
Fixed drug eruption (FDE); Changing Scenario of incriminating drugs.
16) Intraepidermal CD8+ T cells with an effector-memory phenotype resident in fixed drug eruption lesions have a major part to play in the development of localized tissue damage.
Fixed drug eruptions can appear anywhere on the body as single or multiple sharply demarcated, pruritic erythematous macules (Photo 3).
Most common clinical pattern observed was fixed drug eruptions seen in 30 cases, similarly fixed drug eruptions as most common clinical pattern was seen in other studies, Thappa et al.
Fixed drug eruptions are blistering or erosive allergic reactions that may appear on hair-bearing skin, mucus membranes, or modified mucus membranes.
For example, fixed drug eruptions can sometimes manifest with herpeslike genital lesions, as can allergic contact dermatitis following exposure to condoms, semen, or benzocaine sprays used by some men to delay ejaculation.
Results Out of total twenty patients 9 (45%) had fixed drug eruptions 4 (20%) urticaria 3 (15%) Stevens-Johnson syndrome 2 (10%) morbilliform rashes and 2 (10%) had erythema multiforme.

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