first-pass elimination

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First-pass effect, first-pass metabolism, presystemic elimination Pharmacology The rate at which circulating drugs are metabolized as they traverse the liver, before they reach the systemic circulation

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biotransformation
enzyme induction

therapeutic drug monitoring
zero order kinetics

This is most likely the result of first-pass elimination of a medication or drug during oral consumption.

Urticaria Associated With Parenteral Nutrition by James S Scolapio and Marcus Ferrone and Robert A Gillham / JPEN, Journal of Parenteral and Enteral Nutrition

Other advantages include: 1) rapid systemic absorption; 2) quicker onset of therapeutic activity (versus oral); 3) lower required doses and fewer side effects (in some cases); 4) increased patient compliance (versus injection); and 5) avoidance of hepatic first-pass elimination and/or gastrointestinal metabolism of the drug.

Nastech Pharmaceutical Co. - Investment Opinion - 'Buy' by Business Wire

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