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first-pass elimination

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first-pass elimination
First-pass effect, first-pass metabolism, presystemic elimination Pharmacology The rate at which circulating drugs are metabolized as they traverse the liver, before they reach the systemic circulation


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Other advantages include: 1) rapid systemic absorption; 2) quicker onset of therapeutic activity (versus oral); 3) lower required doses and fewer side effects (in some cases); 4) increased patient compliance (versus injection); and 5) avoidance of hepatic first-pass elimination and/or gastrointestinal metabolism of the drug.
 
 
 
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