first-pass elimination

first-pass elimination

First-pass effect, first-pass metabolism, presystemic elimination Pharmacology The rate at which circulating drugs are metabolized as they traverse the liver, before they reach the systemic circulation
References in periodicals archive ?
Other advantages include: 1) rapid systemic absorption; 2) quicker onset of therapeutic activity (versus oral); 3) lower required doses and fewer side effects (in some cases); 4) increased patient compliance (versus injection); and 5) avoidance of hepatic first-pass elimination and/or gastrointestinal metabolism of the drug.