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first-pass effect

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first-pass effect
the metabolism of orally administered drugs by gastrointestinal and hepatic enzymes, resulting in a significant reduction of the amount of unmetabolized drug reaching the systemic circulation.


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Hana believes that drug delivery via a spray to the oral mucosa may in part avoid degradation in the gastrointestinal tract and metabolism by liver enzymes--the so-called first-pass effect.
Drug delivery via a spray to the oral mucosa is designed to avoid degradation in the gastrointestinal tract and metabolism by liver enzymes -- the so-called first-pass effect.
Drug delivery via a spray to the oral mucosa avoids degradation in the gastrointestinal tract and metabolism by liver enzymes -- the so-called first-pass effect.
 
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