first-pass effect

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first-pass effect

the metabolism of orally administered drugs by gastrointestinal and hepatic enzymes, resulting in a significant reduction of the amount of unmetabolized drug reaching the systemic circulation.

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first-pass elimination
Ketek

telithromycin

Hana believes that drug delivery via a spray to the oral mucosa may in part avoid degradation in the gastrointestinal tract and metabolism by liver enzymes--the so-called first-pass effect.

Hana Biosciences Presents Zensana(TM) (ondansetron HCl) Oral Spray ... by Business Wire

Drug delivery via a spray to the oral mucosa is designed to avoid degradation in the gastrointestinal tract and metabolism by liver enzymes -- the so-called first-pass effect.

Hana Biosciences Reaffirms Expected Timing of First NDA Filing by Business Wire

Drug delivery via a spray to the oral mucosa avoids degradation in the gastrointestinal tract and metabolism by liver enzymes -- the so-called first-pass effect.

Hana Biosciences Successfully Completes Pivotal Trials of ... by Business Wire

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