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Any of a group of cephalosporin antibiotics capable of killing gram-positive cocci such as Staphylococcus aureus, streptococci, and some aerobic gram-negative rods. These agents are used to treat skin and soft tissue infections, uncomplicated respiratory tract infections, and urinary tract infections. Examples of first-generation cephalosporins are cephalothin, cephaloridine, cephapirin, cefazolin, cephradine, cephalexin, and cefadroxil.
See also: cephalosporin