Major finding: Use of a first-generation antipsychotic
agent was independently associated with a 3.
19) Studies have mainly focused on atypical antipsychotics, and there is relatively little information on first-generation antipsychotics
The studies also support previous studies which indicated that low doses of first-generation antipsychotics
such as haloperidol are effective and well tolerated in patients with first-episode schizophrenia.
Patients treated with second-generation antipsychotics are less likely to experience treatment-emergent extrapyramidal symptoms and tardive dyskinesia than patients treated with first-generation antipsychotics
Recent reports show that first-generation antipsychotics
are less expensive than the newer drugs.
Randomised control trial of the effect on quality of life of second- vs first-generation antipsychotic
drugs in schizophrenia: Cost utility of the latest antipsychotic drugs in schizophrenia study (CUtLASS 1).
1) Also of great benefit is a decreased propensity for extrapyramidal side effects and tar-dive dyskinesia compared with the older first-generation antipsychotic
agents (such as haloperidol).
Although SGAs were developed to have fewer and less severe side effects than first-generation antipsychotic
drugs, patients taking Zyprexa are being diagnosed with serious metabolic diseases significantly more often than people taking comparable drugs.
Common side effects shared by first-generation antipsychotic
drugs, the so-called typical antipsychotics, include certain types of involuntary muscle contractions or movement, cardiovascular effects, and sedation.
The first-generation antipsychotics
have been grandfathered in with [Food and Drug Administration] approval.
Until now, long-acting injection formulations have been available only for older, first-generation antipsychotics
The Lancet Second-generation vs First-Generation Antipsychotics