first-generation antipsychotic


Also found in: Dictionary, Thesaurus, Wikipedia.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)
See also: antipsychotic
References in periodicals archive ?
Major finding: Use of a first-generation antipsychotic agent was independently associated with a 3.
19) Studies have mainly focused on atypical antipsychotics, and there is relatively little information on first-generation antipsychotics.
The studies also support previous studies which indicated that low doses of first-generation antipsychotics such as haloperidol are effective and well tolerated in patients with first-episode schizophrenia.
Patients treated with second-generation antipsychotics are less likely to experience treatment-emergent extrapyramidal symptoms and tardive dyskinesia than patients treated with first-generation antipsychotics.
Recent reports show that first-generation antipsychotics are less expensive than the newer drugs.
Randomised control trial of the effect on quality of life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost utility of the latest antipsychotic drugs in schizophrenia study (CUtLASS 1).
1) Also of great benefit is a decreased propensity for extrapyramidal side effects and tar-dive dyskinesia compared with the older first-generation antipsychotic agents (such as haloperidol).
Although SGAs were developed to have fewer and less severe side effects than first-generation antipsychotic drugs, patients taking Zyprexa are being diagnosed with serious metabolic diseases significantly more often than people taking comparable drugs.
Common side effects shared by first-generation antipsychotic drugs, the so-called typical antipsychotics, include certain types of involuntary muscle contractions or movement, cardiovascular effects, and sedation.
The first-generation antipsychotics have been grandfathered in with [Food and Drug Administration] approval.
Until now, long-acting injection formulations have been available only for older, first-generation antipsychotics.
The Lancet Second-generation vs First-Generation Antipsychotics Meta-analysis 102