fipronil


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fipronil

(fip-rō'nil),
A phenylpyrazole parasiticide agent that is available as pourable topical solution and spray for flea and tick infestation in dogs and cats; mechanism of action is to disrupt chloride passage through gamma amino butyric acid-mediated channels in nerve cell membranes, resulting in terminal neurologic malfunction. Commercial solutions are flammable.

fipronil

a reversible GABA-receptor inhibitor that acts on the nervous system of insects. Used topically in flea control programs.
References in periodicals archive ?
The flat growth was attributed to several factors: a colder than normal winter and spring, which greatly affected flea and tick medication sales; significant erosion of the market-leading Frontline brand, which felt the effects of its fipronil patent expiration as it loses sales to lower-priced alternatives; and something of a scale-back in revenue in several products that launched in 2012 and received less marketing support in 2013.
Limited Tenders are invited for Supply of Fipronil Spot on liquid 9.
A second study, begun in Connecticut during 2012, uses a similar design to evaluate the effectiveness of bait boxes that apply fipronil to rodents that are the reservoirs of B.
com)-- Unlike sprinkle-on bait products, Fipronil eliminates all ant nests and prevents unwanted future improvements.
For example, mole crickets can detect insect pathogens, the insecticides bifenthrin and fipronil, and avoid areas treated with them (Thompson & Brandenburg 2005; Cummings et al.
Fipronil (the drug in frontline), at the correct dose, is one of the best flea treatments you can get without a prescription.
PetArmor Plus contains fipronil, a veterinarian-recommended active ingredient and (s)-methoprene to protect against fleas, ticks and lice.
He came across other pet owners who were beginning to doubt the efficacy of fipronil.
In another in vitro study comparing the neurotoxicity of fipronil to chlorpyrifos, fipronil induced more oxidative stress and resulted in lower cell counts for nondifferentiated PC12 cells than chlorpyrifos, and disrupted cell development at lower thresholds, leading the authors to conclude that fipronil was in fact more detrimental to neuronal cell development than chlorpyrifos (Lassiter et al.
In his first study, Lizotte looked at how effectively an experimental wetland along Mississippi's Coldwater River trapped atrazine, S-metolachlor, and fipronil, which are commonly used as crop pesticides.
Experts who assessed more than 800 scientific studies published over the past two decades called for a tightening of regulations governing the insecticides known as neonicotinoids and fipronil, and for plans to cut their global use.
Several other fipronil products have made a splash, gnawing away at Frontline's market share.