Studies of in utero exposure of C57BL/6J embryos to TCDD by gavage of the dam showed accelerated expression of filaggrin
at E16 and the presence of a morphologically well-organized epidermis in these TCDD-exposed embryos (Loertscher et al.
mutations associated with skin and allergic disease.
Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao X Liao H, Lee SP, et al: Common loss-of-function variants of the epidermal barrier protein filaggrin
are a major predisposing factor for atopic dermatitis.
The research - by scientists from Canada, the UK, Ireland and the Netherlands - discovered that the Filaggrin
gene helped to make the skin a good barrier against irritants and allergens.
gene helps build barriers in the skin to protect the body against irritants and allergens.
helps stop allergy-causing substances getting through our skin.
is a protein in the outermost layers of the skin and is produced by the filaggrin
Original tests for the detection of autoantibodies to citrullinated proteins detected APF or AKA in patient sera by utilizing filaggrin
antigens and indirect immunofluorescence.
Recent research on atopic disorders has found that a genetically-produced protein called filaggrin
is linked to the cause.
The researchers found that caspase-14 is responsible for processing filaggrin
(NOTE--SPELLING IS CORRECT), a compound that combines keratin and other proteins in the upper layer of the epidermis to form the stratum corneum.
proteins and ceramides in the skin are either missing or not functioning correctly which can disrupt the protective outer layer of the skin, resulting in severe dryness, redness and itching.
In the study, histologic analyses also showed that improved spongiosis scores in treated patients correlated with increased density of two tight junction proteins, filaggrin
(P = .