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field cancerization

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field cancerization
Field carcinogenesis Molecular oncology The constellation of locoregional changes triggered by long-term exposure of a field of tissue to a carcinogen; FC may induce CA, CIS or dysplasia, which can be recognized histologically; the remaining 'field,' despite adequate resection, is grossly normal but more susceptible to future CA; FC occurs in any embryologic tissue–eg, colorectal, breast ducts, bladder, bronchial, laryngeal epithelia, and aerodigestive tract in tobacco exposure. See 'Cancerization.'.


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This finding is very much in concert with the theory of field cancerization or "condemned mucosa," which was popularized by Slaughter et al.
Introduction The original concept of field cancerization was proposed by Slaughter et al in 1953 to explain the high local recurrence rate of oral cancer.
There is ample evidence to support the notion that field cancerization exists in the breast.
 
 
 
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