field cancerization

field cancerization

Field carcinogenesis Molecular oncology The constellation of locoregional changes triggered by long-term exposure of a field of tissue to a carcinogen; FC may induce CA, CIS or dysplasia, which can be recognized histologically; the remaining 'field,' despite adequate resection, is grossly normal but more susceptible to future CA; FC occurs in any embryologic tissue–eg, colorectal, breast ducts, bladder, bronchial, laryngeal epithelia, and aerodigestive tract in tobacco exposure. See 'Cancerization. '.
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It's the corner stone of field cancerization theory which was introduced by Slaughter for first time.
The most recent imaging advances ranging from measuring in transit melanoma metastases, visualization of field cancerization, monitoring non-invasive treatment of skin cancer and even diagnosis of onychomycosis Session Info: will be discussed.
Slaughter et al in 1953 first postulated the concept of field cancerization as follows: the entire epithelial surface of the upper aerodigestive tract has an increased risk for the development of premalignant lesions because of multiple genetic abnormalities in the whole tissue region.
Genetic progression model for head and neck cancer: implications for field cancerization.
A field cancerization around actinic keratosis lesions forms an area with pre-neoplastic anomalies and infra-clinical and multifocal genetic mutations that can evolve into primitive new tumours and local recurrences.
For field cancerization, we need field therapy," agreed Dr.
This finding is very much in concert with the theory of field cancerization or "condemned mucosa," which was popularized by Slaughter et al.
The concept of field cancerization implies that cancers that develop at disparate sites with similar histopathologic patterns do not represent isolated carcinogenic pathways but rather that the sequential genetic changes and cellular events toward carcinogenesis share common pathways among the multiple isolated lesions.
There is a close regional coexistence of invisible (subclinical AK lesions) as well as clinical visible AK lesions on areas of sun exposed skin - a phenomenon which is called field cancerization.
However, all reports agree that multifocal tumors may arise either as metastases from a single tumor or as independent tumors resulting from field cancerization.
The original concept of field cancerization was proposed by Slaughter et al in 1953 to explain the high local recurrence rate of oral cancer.