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field cancerization

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field cancerization
Field carcinogenesis Molecular oncology The constellation of locoregional changes triggered by long-term exposure of a field of tissue to a carcinogen; FC may induce CA, CIS or dysplasia, which can be recognized histologically; the remaining 'field,' despite adequate resection, is grossly normal but more susceptible to future CA; FC occurs in any embryologic tissue–eg, colorectal, breast ducts, bladder, bronchial, laryngeal epithelia, and aerodigestive tract in tobacco exposure. See 'Cancerization.'.


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These changes are accompanied by the accumulation of chromosomal abnormalities throughout the airway mucosa, a process known as field cancerization (14, 15).
This finding is very much in concert with the theory of field cancerization or "condemned mucosa," which was popularized by Slaughter et al.
Most significantly, younger ages of smoking initiation were associated with a higher prevalence of chromosomal deletions within the specific genomic region implicated in field cancerization in the lung (i.
 
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