field cancerization

field cancerization

Field carcinogenesis Molecular oncology The constellation of locoregional changes triggered by long-term exposure of a field of tissue to a carcinogen; FC may induce CA, CIS or dysplasia, which can be recognized histologically; the remaining 'field,' despite adequate resection, is grossly normal but more susceptible to future CA; FC occurs in any embryologic tissue–eg, colorectal, breast ducts, bladder, bronchial, laryngeal epithelia, and aerodigestive tract in tobacco exposure. See 'Cancerization. '.
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The concept of field cancerization was introduced by Slaughter et al.
A surgeon's inability to estimate tumor margins exactly at the first look and accordingly surgical margin positivity can be explained with possible field cancerization or possible submucosal spread beyond the clinically and microscopically identifiable tumor.
BOSTON -- Field cancerization poses unique treatment challenges, but useful approaches to managing patients with such extreme dermatoheliosis are emerging, according to Anokhi Jambusaria-Pahlajani, MD.
It's the corner stone of field cancerization theory which was introduced by Slaughter for first time.
The concept of field cancerization or "condemned mucosa syndrome" is the most popular theory put forward to explain the development of multiple cancers.
Slaughter et al in 1953 first postulated the concept of field cancerization as follows: the entire epithelial surface of the upper aerodigestive tract has an increased risk for the development of premalignant lesions because of multiple genetic abnormalities in the whole tissue region.
Genetic progression model for head and neck cancer: implications for field cancerization.
For field cancerization, we need field therapy," agreed Dr.
Key words: cigarette smoking, field cancerization, lung cancer, susceptibility, tobacco.
There is a close regional coexistence of invisible (subclinical AK lesions) as well as clinical visible AK lesions on areas of sun exposed skin - a phenomenon which is called field cancerization.
They experience early onset of multiple AKs, with field cancerization and up to a 100-fold increased risk of squamous cell carcinomas (SCCs).