ficolin

fi·co·lin

(fi'kō-lin),
A protein that structurally resembles mannose-binding lectin (MBL). The polypeptide chains have a N-terminal region, a collagenlike domain, and a globular region, which is fibrinogenlike. Although H-ficolin and L-ficolin are plasma proteins generated in the liver, M-ficolin is produced by monocytes, and is membrane bound. H- and L-ficolin can form oligomers and are capable of activating complement. M-ficolin may act as a phagocytic receptor on circulating monocytes for glycosylated proteins.
See also: L-ficolin, H-ficolin.
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LP is activated by binding of mannose binding lectin (MBL) or ficolin to pathogen-associated molecular patterns (PAMPs) on the surface of microbes.
After blocking the endogenous peroxidase with 30 g/L hydrogen peroxide, for ficolin staining alone, sections were incubated in TBS with normal sheep serum, with either H-ficolin monoclonal antibody (clone 4H5) from HyCult Biotechnology or rabbit polyclonal anti-L-ficolin antibody (clone 2F5) from Tokai University.
DIFFERENTIAL PLASMA FICOLIN CONCENTRATIONS IN PREECLAMPTIC PREGNANCIES
The low circulating ficolin concentrations suggested an underlying mechanism of ficolins in preeclampsia.
To understand the role of ficolins in the underlying immune recognition in preeclampsia, we revealed high concentrations of H-ficolin and L-ficolin in placental lysate from established preeclamptic pregnancies (n = 5; Fig.
Enhanced trophoblastic apoptosis induces placental and systemic innate immunity through specific ficolin binding.
Specific ficolin binding to the dysfunctional placenta may therefore occur before clinical preeclampsia develops.
P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients.
INCREASED FICOLINS IN PHYSIOLOGICAL IMMUNITY DURING NORMAL PREGNANCIES
Ficolins are pattern-recognition lectins involved in the lectin-complement pathway; they play an important role in innate immunity (6).
SPECIFIC BINDING OF FICOLINS TO PREECLAMPTIC PLACENTAS
These include complement components, collectins, ficolins, and pentraxins.