FBLN5

(redirected from fibulin-5)

FBLN5

A gene on chromosome 14q32.1 that encodes a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains, which promotes adhesion of endothelial cells by interaction of integrins and the RGD motif. The FBLN5 protein produced is expressed in intimal vascular smooth muscle cells and endothelial cells during vascular development, and in remodeling during atherosclerosis and after balloon-catheter-induced injury.

Molecular pathology
FBLN5 mutations cause cutis laxa type I and age-related macular degeneration type 3.
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References in periodicals archive ?
Elastin is made from its precursor molecule tropoelastin, which forms elastic fibers after key steps involving the enzyme lysyl oxidase-like 1 (LOXL1) and glycoprotein fibulin-5 (FBLN5).
Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis.
We found that the protein fibulin-5, which until now simply has been known to be important in generating elastic fibers, actually blocks the enzymes that degrade proteins that support the vaginal wall structure," explains gynecologist R.
Fibulin-5 mutations: mechanism of impaired elastic fibre formation in recessive cutis laxa.
Also new from LS is Elestan, a Manilkara extract that works four ways in anti-aging products: it has an anti-glycation effect, protects against elastases, stimulates (tropo) elastin synthesis and ensures optimal structuring of the elastic fiber network through the stimulation of Emilin-1 and Fibulin-5, both of them elastin-associated proteins.
One of the main reasons elastin production decreases as we age is due to diminishing levels of the enzymes lysyl oxidase-like 1 (LOXL1) and glycoprotein fibulin-5 (FBLN5).