EFEMP1

(redirected from fibulin-3)

EFEMP1

A gene on chromosome 2p16 that encodes a member of the fibulin family of extracellular matrix glycoproteins, which contain tandemly repeated epidermal growth factor (EGF)-like repeats followed by a C-terminus fibulin-type domain.

Molecular pathology
EFEMP1 is upregulated in malignant gliomas and may play a role in tumour aggression; EFEMP1 mutations cause Doyne honeycomb retinal dystrophy.
Mentioned in ?
References in periodicals archive ?
This gene produces a protein, fibulin-3, that is present in levels four to five times higher in the plasma of patients with mesothelioma compared to levels in asbestos-exposed patients or patients with several other conditions that cause tumors in the chest," says lead investigator Harvey I.
Fibulin-3 is a protein that floats outside cells, coating the cells and free floating in blood plasma and extracellular fluid.
To test how specific the over-expression of fibulin-3 is to mesothelioma, they compared levels of the protein in the plasma of patients with mesothelioma to the plasma Levels of the protein in patients afflicted by a variety of different types of cancer resulting in chest tumors.