FBLN1

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FBLN1

A gene on chromosome 22q13.31 that encodes fibulin-1, a secreted glycoprotein incorporated into a fibrillar extracellular matrix by laminin and nidogen binding. Fibulin is involved in cell adhesion and migration along protein fibres within the ECM; it may be critical for development and contribute to the ECM supramolecular organisation, especially of basement membranes. It has been implicated in cell transformation and tumour invasion, and may be a tumour suppressor; it plays a role in haemostasis and thrombosis by binding fibrinogen and incorporating itself into blood clots. It may also modulate the neurotrophic activities of APP, especially soluble APP.
References in periodicals archive ?
Our investigations led to the identification of a candidate molecule, fibulin-1, an elastin-associated matrix molecule, which is also present in large concentrations in plasma.
Similarly, intima/media preparations from 2 groups (diabetic, n = 7; nondiabetic, n = 7) were gathered for protein extraction and fibulin-1 quantification (population 2, Table 1).
POPULATION 3: PLASMA FIBULIN-1 CASE-CONTROL STUDY (T2DM VS NONDIABETES)
EDTA-anticoagulated blood for analysis of plasma fibulin-1 was obtained from 305 T2DM patients without known or suspected CVD, consecutively referred to the outpatient diabetes clinic at Odense University Hospital, Denmark (17) (population 4, Table 1).
POPULATION 5: PLASMA FIBULIN-1 FOLLOW-UP STUDY (T2DM AND MORTALITY)
EDTA-plasma specimens from baseline investigation, available from 308 of 315 patients followed for 15 years (range 0-17 years) (18) were analyzed for fibulin-1.
Slides were stained with fibulin-1 anti-bodies and evaluated quantitatively as described in the Data Supplement that accompanies the online version of this article at http://www.
A sandwich immunoassay for fibulin-1 was set up that was based on a previously described method (22),as described in detail in the online Supplementa Data file.
Cox proportional hazard models were used to evaluate fibulin-1 as a predictor of overall or cardiovascular mortality.
IDENTIFICATION OF FIBULIN-1 BY GLOBAL GENE EXPRESSION ANALYSIS IN NORMAL-APPEARING TISSUE IN DIABETES
Immunohistological analysis showed fibulin-1 immunolabeling to be present throughout the layers of the arterial wall (Fig.
Fibulin-1, vitronectin, and fibronectin expression during avian cardiac valve and septa development.