FBLN2

(redirected from fibulin 2)

FBLN2

A gene on chromosome 3p25.1 that encodes fibulin-2, a secreted glycoprotein of the fibulin family that binds various extracellular ligands and calcium and plays a key role during organogenesis, especially during the differentiation of the heart, muscle and brain.
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We performed quantitative real-time PCR (q-RT-PCR) using random hexamer primers and Taqman gene expression assays (Applied Biosystems Prism 7700) for von Willebrand factor (VWF)12 (Hs01109460_m1); leptin (LEP) (Hs00174877_m1); matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2) (Hs00234422_m1); fibulin 1 (FBLN1) (Hs00242546_m1); and fibulin 2 (FBLN2) (Hs01002054_m1).
Further investigation revealed that the MS FBN1 protein interacted directly with the proteins of four of the 88 genes - fibulin 1 (FBLN1), fibulin 2 (FBLN2), Decorin (DCN) and microfibrillar associated protein 5 (MFAPS5).