4] Several reports indicate that atypical fibroxanthoma
is also rarely capable of metastasis.
The differential diagnosis includes ossifying hematoma, branchial cyst, adenopathy, preauricular cyst, giant-cell tumor, chondroma, fibroxanthoma
, foreignbody reaction, and osteoma cutis.
Skin cancer can include squamous cell carcinoma, basal cell carcinoma, melanoma, sarcoma, Merkel cell carcinoma, angiosarcoma, verrucous carcinoma, atypical fibroxanthoma
, and leiomyosarcoma.
The term is synonymous with inflammatory pseudotumor, infantile omental-mesenteric myxoid hamartoma, and fibroxanthoma
2) Alternate terminology includes pulmonary pseudotumor, plasma cell granuloma, inflammatory myofibroblastic tumor, fibroxanthoma
, xantho matous pseudotumor, and plasma cell-histiocytoma complex.
One patient had a fibroxanthoma
of the frontal sinus, and the other had extramedullary hematopoiesis of the maxillary sinus.
They include atypical fibroxanthoma
, spindle-cell carcinoma, amelanotic malignant mucosal melanoma, osteosarcoma, fibrosarcoma, pleomorphic rhabdomyosarcoma, pleomorphic liposarcoma, dedifferentiated sarcomas, and glioblastoma multiforme.
Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma
Recent studies showed that CD99 labeled 17 of 17 cases (100%) and 19 of 26 cases (73%) of atypical fibroxanthoma
, with most showing a moderate to strong staining pattern.
Cases with atypical cytologic characteristics may simulate atypical fibroxanthoma
, leiomyosarcoma, malignant peripheral nerve sheath tumors, other sarcomas, or sarcomatoid carcinomas.
The histogenesis and classification of fibrohistiocytic lesions involving bone and containing an admixture of fibrous tissue, foam cells, and giant cells are confusing and include several overlapping entities, such as metaphyseal fibrous defect, nonossifying fibroma, fibrous cortical defect, fibroxanthoma
, and benign fibrous histiocytoma (BFH) of bone.
However, the differential diagnosis for lesions with this appearance is wide and includes: sebaceous cysts, ossifying hematomas, giant-cell tumors, chondromas, dermoid cysts, foreign body reactions, degenerating fibroxanthomas
, metastatic bone formations and osteoma cutis.