233,234) Examples include lipoma, leiomyoma, granular cell tumor, schwannoma, gangliocytic paraganglioma, glomus tumor, inflammatory myofibroblasts tumor, plexiform fibromyxoma
(plexiform angiomyxoid myofibroblasts tumor), leiomyosarcoma, angiosarcoma, Kaposi sarcoma, and synovial sarcoma, which are immunophenotypically similar to their counterparts in other locations.
Since DC usually presents as a unilocular, well-defined radiolucent lesion without prominent clinical symptoms, differential diagnosis should include the radicular cyst, odontogenic keratocyst, ameloblastoma, odontogenic fibromyxoma
and odontoma (4, 9).
In Superficial Acral Fibromyxoma
, neutrophils and Epithelial component are rare but with Prominent fibrous component mixed/alternating with moderately cellular myxoid areas and EMA variably positive.
dermal fibroma), (6) pleomorphic fibroma, (7) cellular digital fibroma, (8) superficial acral fibromyxoma, (9) pleomorphic hyalinizing angiectatic tumor of soft parts, (10) and malignant lesions such as dermatofibrosarcoma protuberans (DFSP).
Superficial Acral Fibromyxoma (Digital Fibromyxoma).
The main differential diagnoses of nasal masses with similar MRI/CT findings as schwannoma include nasal polyp, malignant peripheral nerve sheath tumors (MPNST), myxoma & fibromyxoma, Lobular Capillary hemangioma (LCH) and sarcoma.
Nasal polyps usually have high signal intensity on T2-weighted images, which helps to distinguish them from tumors; Myxoma & fibromyxoma are benign neoplasm of uncertain histogenesis with characteristic histologic appearance.
It is also an endothelial marker and stains solitary fibrous tumor, spindle cell lipoma, superficial acral fibromyxoma, sclerotic fibroma, Kaposi sarcoma, neurofibroma, tricholemmoma, scleromyxedema, and nephrogenic systemic fibrosis, among others.
Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans.
Superficial acral fibromyxoma
(SAFM) is a rare, slow-growing, solitary, soft tissue tumor, which was initially described by Fetsch et al (1) in 2001.
Renal cell carcinoma, fibromas and fibromyxomas
are also reported as rare occurrences in the camelids with few reports of papillomas and melanomas.