fibrogenic

fibrogenic

adjective Referring to or causing the formation of fibrous tissue; fibroplastic.
References in periodicals archive ?
CVC is an oral, once-daily, potent immunomodulator that blocks two chemokine receptors, CCR2 and CCR5, which are intricately involved in the inflammatory and fibrogenic pathways in NASH that cause liver damage and often lead to cirrhosis, liver cancer or liver failure.
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.
TGF-P also induces fibrogenic transdifferentiation of tubular epithelial cells to harbor ECM-producing character (Li et al.
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis.
Irritants or corrosive chemicals can cause inflammation, burns, or blisters, fibrogenic materials lead to a loss of lung function, allergic reactions can lead to asthma-type diseases, or dermatitis.
2A] receptor on hepatic stellate cells, the principal fibrogenic cell type in the liver, and promotes the production of matrix proteins, including collagen types I and III, suppressing the production of some matrix metalloproteinases.
RHAMM mRNA and protein are poorly expressed in most normal human tissues (21) but RHAMM expression increases in pathologic conditions such as wound repair in response to hypoxia and fibrogenic factors (TGF[beta]1) (22).
This category acknowledges the observation that cases of treated pancreatic cancer, even cases with the most dramatic fibrogenic response, typically have at least rare residual tumor cells present; only rarely, do pancreatic cancers demonstrate a complete absence of tumor cells following neoadjuvant therapy.
Thus, this well-known fibrogenic cytokine is important both for the emergence of the myofibroblast and its survival against apoptotic stimuli.
Curcumin, resveratrol, and other GRAS botanical extracts are well known to be effective anti-inflammatory agents, as well as substances that can halt the activation of NFkappaB, acting in direct ways to modulate the body's fibrogenic response to Hepatitis B and C infections.
Strong evidence indicates that various MMP/TIMP imbalances are crucial elements in the fibrogenic process.
Leptin is essential for the hepatic fibrogenic response to chronic liver injury.