Despite the observation of cardiac chamber enlargement and systolic dysfunction, which could suggest the presence of dilated cardiomyopathy, the dogs did not undergo genetic evaluation or any identification of myocardial fibrofatty
infiltration for confirmation of the disease; thus, the number of ventricular arrhythmias in 24 hours was the only diagnostic criterion used.
2) Such cases with full-thickness fibrofatty
replacement readily transilluminate (Figure 1).
Table 1: Investigations performed in November to December 2012 Bone marrow biopsy Metastatic carcinoma IHC Atypical cells positive for PAN-CK These cells expressed CK-7 positivity Expressed nuclear positivity for ER and PR Her-2 neu showed cytoplasmic staining Tumor cells negative for CK 20 and MPO stains Bilateral mammogram ACR BIRADS assessment category 0 No definitive mammographic evidence of malignancy Dense nature of breast parenchyma FNAC Rt breast lump Fibrofatty
fragment and small cohesive cluster of ductal epithelial cells; no malignant cells Rt axillary nodes BC--fibrofatty
tissue; scattered lymphoid cells Rt supraclavicular node No definitive opinion possible Whole-body PET-CT scan Bone marrow showed metastatic Ca.
Sometimes the residual fibrofatty
tissue may mimic a recurrence to an unwary eye.
We create a bone window by freeing the bone from the overlying fibrofatty
tissue and periosteum.
5cm of fibrofatty
sleeve should be left on each side of pedicle.
It usually manifests as a soft slowly growing mass consisting of proliferating fibrofatty
tissue surrounding and infiltrating major nerves and their branches (1-3).
The valve is bound superolaterally by the caudal edge of the upper lateral cartilage, and the lateral border includes the bony piriform aperture and the fibrofatty
tissue of the ala.
7,8,21 Use of a single haematoxylin and eosin (H and E) stain reveals the key features of muscular dystrophies like variation in fiber size and shape, internal nuclei, fiber splits, necrosis, myophagocytosis and fibrofatty
metaplasia giving more than 50% information about the biopsy.
3-5) The precise aetiology is unknown; however, there are many hypotheses suggesting that it is due to fibrofatty
tumours impinging on nerves supplying the enlarged digit, or due to alteration of somatic cells during limb bud development.
Fontaine et al (2) described an entity, called arrhythmogenic right ventricular dysplasia, which was characterized, by localized deficiency or fibrofatty
tissue replacement of right ventricular myocardium.
Colocalization implicates TGF-beta in fibrofatty