The company is developing its lead candidate palovarotene, a novel retinoic acid receptor gamma agonist, to treat fibrodysplasia ossificans progressiva
(FOP) and other diseases.
Classic and atypical fibrodysplasia ossificans progressiva
(FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.
For more information about fibrodysplasia ossificans progressiva
, go to www.
For more information, contact: International Fibrodysplasia Ossificans Progressiva
About Fibrodysplasia Ossificans Progressiva
(FOP) FOP is a rare, severely disabling disease characterized by painful, recurrent episodes of soft tissue swelling (flare-ups) that result in new, abnormal bone formation in muscles, tendons and ligaments.
The topper, though, was "stone man syndrome", or fibrodysplasia ossificans progressiva
4) Finally, many systemic diseases can lead to auricular ossification, including congenital plaque-like osteomatosis, Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva
, Addison disease, osseous heteroplasia, and collagen vascular diseases, especially CREST syndrome and childhood dermatomyositis.
Floyd, 13, has fibrodysplasia ossificans progressiva
, a disease that causes bone cells to form within muscles, tendons, and other connective tissue - forming a second skeleton and eventually immobilizing the body.
Fibrodysplasia Ossificans Progressiva
is a disease in which normal bone forms in muscles, tendons and ligaments creating an extra skeleton that immobilizes the body.
Daniel has fibrodysplasia ossificans progressiva
(also called FOP, it is a rare genetic disorder that causes bone to form in the body's healthy tissues.
60 million mezzanine round of financing to support the ongoing development of the Company's lead compound palovarotene for the treatment of fibrodysplasia ossificans progressiva
today announced the opening of a new site in Paris, France for the Phase 2 clinical trial of palovarotene, the company's lead product candidate for the treatment of fibrodysplasia ossificans progressiva