fibrocystic


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Related to fibrocystic: Fibrocystic Disease

fibrocystic

 [fi″bro-sis´tik]
characterized by an overgrowth of fibrous tissue and the development of cystic spaces, especially in a gland.
fibrocystic disease of breast a disorder characterized by single or multiple benign tumors in the breast; it is the most common disorder of premenopausal women between the ages of 30 and 55, has a familial tendency, and usually abates after menopause. It is due to abnormal hyperplasia of the ductal epithelium and dilatation of the ducts of the mammary gland. Called also chronic cystic mastitis, cystic disease of the breast, and Schimmelbusch's disease.

The tumors of true fibrocystic breast disease can be fluid-filled cysts that arise from glandular elements (blue dome cysts), or solid fibrous growths containing connective tissue elements (fibroadenomas). It was once believed that women with this disorder had a two to three times greater than average risk of developing breast cancer; however, recent studies have shown the risk to be only about 1.6 times greater. Since this disorder does predispose a woman to a breast malignancy, it is recommended that it be carefully monitored by periodic examinations, radiologic studies, and biopsies to identify malignant changes in their earliest stages. Baseline mammography is done for the young patient, and routine regular mammograms are done for the older patient.

Since many cases subside on their own after menopause, it is believed that the cyclic appearance of symptoms is linked to estrogen levels.
Symptoms. The most outstanding symptom of fibrocystic disease of the breast is the presence of one or more lumps in the breast. There also is a feeling of breast fullness and tenderness that is more noticeable each month during the premenstrual period. The presence of cysts and lumps in the breast can produce anxiety for the patient and make self-examination more difficult. Additionally, the frequent examinations needed to rule out malignant changes add to physical discomfort and psychologic stress.
Treatment and Patient Care. Medical treatment usually consists of hormonal therapy with synthetic androgen; a commonly used agent is danazol. Synthetic androgens depress ovarian functions, causing a lessening of symptoms. However, common side effects such as menstrual irregularities, weight gain, edema, and acne do occur. Hormonal therapy is usually reserved for those women who cannot find relief through more conservative therapy.

Among the self-help methods that have been successful are reduction of stressors in their lives and dietary restriction of all forms of methylxanthines, particularly caffeine. If the patient is able to eliminate her intake of caffeine, it usually takes at least two months for the effects of the restriction to become apparent. Other measures that have had varying degrees of success include limiting salt and taking a mild diuretic during the week before menstruation begins, applying warm compresses to the breast, wearing a brassiere that gives good support, and taking a mild nonprescription analgesic for discomfort.

Patient education includes instruction in self-examination of the breast with emphasis on the importance of doing this each month. Once the woman becomes accustomed to the location and size of her breast lumps she is better able to detect any change that might occur. The ideal time for breast self-examination is five to seven days after menstruation when swelling and tenderness are usually at a minimum.
fibrocystic disease of the pancreas cystic fibrosis.

fi·bro·cys·tic

(fī'brō-sis'tik),
Pertaining to or characterized by the presence of fibrocysts.

fibrocystic

/fi·bro·cys·tic/ (-sis´tik) characterized by an overgrowth of fibrous tissue and development of cystic spaces, especially in a gland.

fibrocystic

(fī′brō-sĭs′tĭk)
adj.
Characterized by increased fibrosis and cystic spaces, especially in glandular tissue.

fibrocystic

[-sis′tik]
pertaining to a fibrocyst or cystic fibroma.

fibrocystic

adjective Referring to the structure or tissue with fibrous induration and one or more cyst-like spaces.

fi·bro·cys·tic

(fī'brō-sis'tik)
Pertaining to or characterized by the presence of fibrocysts.

fibrocystic

1. Containing fibrous tissue and cysts.
2. Pertaining to a tumour of fibrous tissue, such as a FIBROMA, which has undergone degeneration with the formation of fluid-filled spaces.
3. Pertaining to CYSTIC FIBROSIS.

fibrocystic

characterized by an overgrowth of fibrous tissue and the development of cystic spaces, especially in a gland.
References in periodicals archive ?
Follow-up of the 20 patients (21 biopsies) who had unremarkable/normal breast tissue on MRI-guided biopsy revealed the following: 11 patients had resolution of the initial lesion on follow-up MRI, 1 patient had a prophylactic mastectomy with concordant benign pathology at the 2 MRI biopsy sites, 4 women underwent rebiopsy that yielded benign breast tissue or fibrocystic changes, 3 women were lost to follow-up, and 1 had a follow-up ultrasound guided biopsy that revealed focal lobular carcinoma in situ in a background of columnar cell change.
Out of 47 patients of fibroadenoma, 10% (12/120) patients were diagnosed with both fibroadenoma and fibrocystic disease.
Pathology report indicated fibrocystic changes (Figure 2), increased stroma and CD34 positivity.
The fibrocystic disease is diagnosed on the basis sonography (sonomammography), mammography, cytological and biochemical assessment of the breast cyst fluid, and histopathology [8, 9].
The most common benign lesion encountered was fibrocystic change, followed by sclerosing adenosis.
According to the company, Violet iodine is based on its latest molecular iodine technology designed to help free women from the burden of breast discomfort by addressing the underlying causes of a condition known as fibrocystic breast condition (FBC), which is thought to be caused by hormonal imbalances that can cause breast tissue growth to exceed its natural cell turnover.
Moreover, the recent report analyzed normal, benign fibrocystic, and malignant breast epithelial cells and found that unique variations in nuclear shape were associated with the malignant cells.
A big focus of discussion was on women's health issues such as advanced therapies in dysmenorrhea, vulvodynia, cervical dysplasia, endometriosis, fibrocystic breast disease, dysfunctional uterine bleeding and amenorrhea.
Blood in breastmilk during pregnancy and lactation can also be caused by serious diseases such as ductal papilloma and fibrocystic disease.
Human breast cancer cell lines (MCF-7 and MDA-MB-231) and a fibrocystic breast cell line (MCF-10a) were either exposed or not exposed to 10 microM lycopene for 48 h.