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Sixteen cases of desmoplastic fibroblastomas were located in the hand ( n = 7), foot ( n = 4), upper arm ( n = 1), forearm ( n = 2), shoulder ( n = 1), and femur ( n = 1; [Table 1]).
In 15 cases of desmoplastic fibroblastomas of soft tissue, ultrasonic examination showed a smooth, heterogeneous hypoechoic mass surrounded by muscular or fat tissue.
The desmoplastic fibroblastomas of soft tissue were well circumscribed, round or oval, and covered by a smooth surface [Figure 1]c.
The desmoplastic fibroblastomas of soft tissue had a clear border and were surrounded by a thin fibrous capsule [Figure 2]a.
1] found that 32 of 63 patients with desmoplastic fibroblastomas emerged conspicuous infiltration into subcutaneous fat, while skeletal muscle infiltration was described in 17 cases, and one-third of the cases were found to have enclosed the nerves.
This study reported one case of desmoplastic fibroblastomas primarily located in the femur, while no soft-tissue tumor was found in the adjacent area of bone desmoplastic fibroblastoma.
Background: Desmoplastic fibroblastoma (collagenous fibroma) is an uncommon benign soft-tissue tumor, rarely involving bone.
Desmoplastic fibroblastoma is an uncommon benign soft-tissue tumor, which was first described by Evans in 1995.
Of the 16 cases of soft-tissue desmoplastic fibroblastoma, 15 were obtained from surgical procedures in the Department of Hand Surgery and one case of bone was derived from a surgical procedure in the Department of Orthopedic Oncology.
Formalin-fixed, paraffin-embedded specimens of 16 cases of desmoplastic fibroblastoma were available for immunohistochemical analysis.
In the one case of desmoplastic fibroblastoma of bone, the X-ray of the right proximal femur showed an osteolytic lesion with a well-defined sclerotic rim, but lack of matrix calcification [Figure 1]b.
Various regions within the alpha- helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas.

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