fibroblast growth factors


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fibroblast growth factors

A family of peptide regulators produced by virtually all cells. Their range of actions is wide. Only some are stimulators of the collagen-producing cells, the fibroblasts. Other effects include strong stimulation of vascular endothelial cell proliferation. Some are produced in relatively large quantities by brain tumours. Hope for people paralysed by spinal cord injuries has been raised by the discovery that a measure of rejoining in severed spinal cord tracts in rats can be achieved using a fibrin ‘glue’ containing a fibroblast growth factor. A mutation in the gene for a fibroblast growth factor receptor can cause CRANIOSYOSTOSIS.
References in periodicals archive ?
Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction.
Boston, a premier cellular therapy company, has obtained an exclusive worldwide license for dimerized fibroblast growth factor (dFGF), a novel protein developed by scientists at Massachusetts Institute of Technology (M.
We conducted a leg ulcer study with fibroblast growth factors last year, applying them directly into the ulcers.
Fibroblast growth factors control nutrient metabolism and are released upon bile acid uptake into the small intestine.
PI-88, is one of a new class of multi-targeted cancer therapeutics inhibiting both angiogenesis or tumor promoting factors such as Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factors 1 and 2 (FGF-1 and -2) and heparanase, an enzyme implicated in tumor metastasis (tumor spread).
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development.
Prizm is developing therapeutic and diagnostic products based on exploiting the regulation of fibroblast growth factors and their receptors.
The importance of fibroblast growth factors (FGFs) in the growth of cancer cells has been known for some time.
Rather than relying on a single mode of action to induce an anticancer response, its anti-angiogenic properties derive from inhibiting multiple growth factors, including Fibroblast Growth Factors (FGFs) and VEGF, as well as inhibiting other angiogenic agents, including heparanase.
Nasdaq:ENDV) under which the parties will collaborate on the development of liposome encapsulated agents to promote angiogenesis, such as fibroblast growth factors and vascular endothelial growth factors, the genes that cause cells to produce such growth factors, and agents to treat congestive heart failure.

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