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degeneration |
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degeneration /de·gen·er·a·tion/ (de-jen″er-a´shun) deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form.degen´erative ascending degeneration wallerian degeneration affecting centripetal nerve fibers and progressing toward the brain or spinal cord. calcareous degeneration degeneration of tissue with deposit of calcareous material. caseous degeneration caseation (2). cerebromacular degeneration (CMD), cerebroretinal degeneration 1. degeneration of brain cells and of the macula retinae. 2. any lipidosis with cerebral lesions and degeneration of the macula retinae. 3. any form of neuronal ceroid-lipofuscinosis. congenital macular degeneration hereditary macular degeneration with a cystlike lesion that in the early stages resembles egg yolk. Crooke's hyaline degeneration Crooke's hyalinization. descending degeneration wallerian degeneration extending peripherally along nerve fibers. disciform macular degeneration a form of macular degeneration seen in persons over age 40, in which sclerosis involving the macula and retina is produced by hemorrhages between Bruch's membrane and the pigment epithelium. fibrinous degeneration necrosis with deposit of fibrin within the cells of the tissue. gray degeneration degeneration of the white substance of the spinal cord, in which it loses myelin and assumes a gray color. hepatolenticular degeneration Wilson's disease. hyaline degeneration a regressive change in cells in which the cytoplasm takes on a homogeneous, glassy appearance; also used loosely to describe the histologic appearance of tissues. lattice degeneration of retina an often bilateral, usually benign asymptomatic condition, characterized by patches of fine gray or white intersecting lines in the peripheral retina, usually with numerous round punched-out areas of retinal thinning or retinal holes. macular degeneration degenerative changes in the macula retinae. mucoid degeneration that with deposit of myelin and lecithin in the cells. myxomatous degeneration degeneration in which mucus accumulates in connective tissues. spongy degeneration of central nervous system , spongy degeneration of white matter a rare hereditary form of leukodystrophy of early onset in which widespread demyelination and vacuolation of cerebral white matter gives it a spongy appearance; there is mental retardation, megalocephaly, atony of neck muscles, limb spasticity, and blindness, with death in infancy. striatonigral degeneration a form of multiple system atrophy with nerve cell degeneration mainly in the region of the substantia nigra and the neostriatum; symptoms are similar to those of parkinsonism. subacute combined degeneration of spinal cord degeneration of posterior and lateral columns of the spinal cord, with various motor and sensory disturbances; it is due to vitamin B12 deficiency and usually associated with pernicious anemia. tapetoretinal degeneration degeneration of the pigmented layer of the retina. transneuronal degeneration atrophy of certain neurons after interruption of afferent axons or death of other neurons to which they send their efferent output. Zenker's degeneration hyaline degeneration and necrosis of striated muscle.
Degeneration Gradual, progressive loss of nerve cells. Mentioned in: Alcohol-Related Neurologic Disease
degeneration (deg) [dijen′ərā′shən] Etymology: L, degenerare, to become unlike others the gradual deterioration of normal cells and body functions. degeneration deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form. When there is chemical change of the tissue itself it is true degeneration; when the change consists in the deposit of abnormal matter in the tissues, it is infiltration. See also wallerian degeneration, Zenker's necrosis. albuminoid degeneration cloudy swelling, an early stage of degenerative change characterized by swollen, parboiled-appearing tissues which revert to normal when the cause is removed. ballooning degeneration swelling of the cytoplasm in epidermal cells without vacuolization, enlarged or condensed nuclei and acantholysis. A characteristic of viral infections of the skin. Called also koilocytosis. caseous degeneration caseation (2). colloid degeneration degeneration with conversion of the tissues into a gelatinous or gumlike material. cystic degeneration degeneration with formation of cysts. fatty degeneration deposit of fat globules in a tissue. feathery degeneration said of hepatocytes; a hydropic change in hepatocytes which have suffered long-term exposure to cholestasis. fibrinoid degeneration deposition or replacement with eosinophilic fibrillar or granular substance resembling fibrin. fibroid degeneration degeneration into fibrous tissue. hyaline degeneration a regressive change in cells in which the cytoplasm takes on a homogeneous, glassy appearance; also used loosely to describe the histological appearance of tissues. Called also hyalinosis. hydropic degeneration see hydropic degeneration. macular degeneration degenerative changes in the macula retinae. mucoid degeneration degeneration with increased mucin which can be epithelial or mesenchymal in origin. mucous degeneration degeneration with accumulation of mucus in epithelial tissues. Called also myxomatous degeneration. myxomatous degeneration see mucous degeneration (above). reticular degeneration extreme intracellular edema of epidermal cells, resulting in rupture and multilocular intraepidermal vesicles with septae formed by the remaining cell walls. Seen in acute inflammatory dermatoses. spongy degeneration on microscopic examination has the physical appearance of a sponge. Usually applied to tissue of the central nervous system, caused by the loss of myelin. Zenker's necrosis, degeneration see Zenker's necrosis.
degeneration Deterioration of tissue or organ resulting in reduced efficiency. Examples: degeneration of the cornea; degeneration of the retina. See corneal dystrophy.
age-related macular degeneration See age-related macular degeneration. cobblestone degeneration See paving-stone degeneration. cone degeneration See cone dystrophy. Doyne's honeycombed degeneration See familial dominant drusen. lattice degeneration of the retina See lattice degeneration of the retina. lipid droplet degeneration See actinic keratopathy. paving-stone degeneration Discrete, yellowish round areas of retinal thinning and depigmentation located near the ora serrata. The underlying choroid may be seen. It is a benign degeneration occurring with advancing age. Syn. cobblestone degeneration; peripheral chorioretinal degeneration. pellucid marginal degeneration A rare condition characterized by bilateral, slowly progressive thinning and protrusion of the inferior peripheral cornea. The involved area is clear (hence the word pellucid), but the condition may be complicated by hydrops and the central cornea typically develops against the rule astigmatism. Treatment usually consists of gas permeable scleral lenses, but keratoplasty may be necessary. See corneal ectasia; hydrops; keratoconus. peripheral chorioretinal degeneration See paving-stone degeneration. peripheral cystoid degeneration A degenerative process in the peripheral retina that occurs almost universally in the elderly. It consists of numerous, discrete cystic spaces in the outer plexiform or inner nuclear layer presenting a frothy appearance. The degeneration starts at the ora serrata and slowly progresses to the peripheral retina. If the cysts should join together, degenerative retinoschisis develops. It is not usually associated with retinal tears. The condition does not require any treatment. Salzmann's nodular degeneration A degenerative condition characterized by bluish-white, elevated nodules on the surface of the cornea. It may occur in people previously affected by trachoma, phlyctenular keratitis, vernal keratitis or keratoconjunctivitis sicca. Most cases are asymptomatic, but if the nodules impair vision, keratoplasty may be necessary. senile macular degeneration See age-related macular degeneration. tapetoretinal degeneration A hereditary degeneration affecting the photoreceptors of the retina or the pigment epithelium layer. Some authors also include the choroid. Syn. tapetoretinopathy. See choroideremia; retinitis pigmentosa. Terrien's marginal degeneration See corneal ectasia. vitreoretinal degeneration See Wagner's disease; Stickler's syndrome. degeneration Medtalk The deterioration or compromise in function of a part. See Age-related macular degeneration, Ballooning degeneration, Fatty degeneration, Feathery degeneration, Granulovacuolar degeneration, Hereditary degeneration, Liquefactive degeneration, Macular degeneration, Myxoid degeneration, Paraneoplastic cerebellar degeneration, Red degeneration, Spongy degeneration of infancy, Wallerian degeneration, Waxy degeneration. Patient discussion about fibrinous degeneration. Q. Is degenerative disc disease and arthritis the same thing? My husband was recently in a auto accident at work. They did a CT Scan of his head and neck. The doctor said that the CT Scan found that he has arthritis in his neck. After receiving the report ourselves to take to another doctor it reads: "There is minimal early degenerative disc disease with osteophyte formation predominately at C5-6. " My husband never had a problem with his neck before the accident A. I also have degenerative disc and osteoarthritis, it is different. I have fibromyalgia, so muscle pain along with the bone and joint pain. I have had two fusions in my c-spine. The osteophyte is a bone spur according to my doctor and he told me they usually start with the onset of arthritis. So good luck and if I can help in anyway with Questions please email me! Q. I am interested in information on working with fibromyalgiaI am having problems just coping at home! I have had 2 c-spine surgeries in 2 years, have degenerative disc disease, maigrains with nuurological tendencies, fatigue, deppression and fibromyalgia. I can't stand for long , sit for long, just making it through my daily life is stressful enough how do people manage to work? I have been off since August of last year but wan to feel well enough so I can return to the working world, Any suggestions? Tried Lyrica, doctor took me off the side affects for me were terrible! A. I had a cervical spinal fusion, C4-5,C5-6 and a SLAP repair of my left shoulder. Initially after the fusion the headaches and tinlging went away and then 4 months later, while in a PT work conditioning prorgam, the headaches returned, along with nausea, vomiting and vertigo. My doctor basically ignored the symptoms for the last 5 months and I was finally referred to a neurologist who is treating me with Lyrica and Imitrex. The side effects are brutal and it has come done to living with the headaches and other symptoms vs. living in a fog unable to function. I have come to realize that there is no magic "fix" and all the meds mask the stymptoms temporarily but it's a tradeoff when you consider the side effects and possible long term health issues from meds such as Lyrica that have no research as far as long term health conditions. I found a natural remedy called Headache Free and I'm giving it a try.....good luck because I know exactly how debilitative these symptoms are Q. Is bipolar degenerative? Does it get worse with age? What can I do with this? Is bipolar degenerative? Does it get worse with age? I am with type II but I get in to severe depression at times. My mania is in short spurts but increasing in intensity. What can I do with this? A. Thank you for sharing your experience richguys... I hope that you find a treatment soon that eleviates the symptoms you have been experiencing... 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