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fibrinolytic agents

   Also found in: Encyclopedia, Wikipedia 0.05 sec.
fibrinolytic agents,
n.pl agents that decrease the breakdown of fibrin.


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With the advent of thrombolytic agents such as urokinase and recombinant tissue plasminogen activator (tPA), a series of promising experimental and clinical studies began to demonstrate the therapeutic benefit of intraventricular administration of fibrinolytic agents for the treatment of IVH.
When compared with older fibrinolytic agents, RETAVASE distinguishes itself by its ease of administration - a simple two-bolus injection given 30 minutes apart.
The use of various fibrinolytic agents (streptokinase, urokinase, and recombinant tissue-type plasminogen activator [rt-PA]) has been reported in a small number of clinical series with a very limited number of participants, yielding significant variability regarding inclusion criteria, treatment protocol, and outcome analysis.
 
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