fibrinolysis


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fibrinolysis

 [fi″brĭ-nol´ĭ-sis]
the dissolution of fibrin by enzymatic action. adj. adj fibrinolyt´ic.
Fibrinolysis. From Copstead, 1995.

fi·bri·nol·y·sis

(fī-bri-nol'i-sis), Avoid the mispronunciation fibronoly'sis.
1. Hydrolysis of fibrin.
2. The process of dissolution of fibrin in blood clots.
[fibrino- + G. lysis, dissolution]

fibrinolysis

/fi·bri·nol·y·sis/ (fi″brin-ol´ĭ-sis) dissolution of fibrin by enzymatic action.fibrinolyt´ic

fibrinolysis

(fī′brə-nŏl′ĭ-sĭs)
n. pl. fibrinoly·ses (-sēz′)
The breakdown of fibrin, usually by the enzymatic action of plasmin.

fi′bri·no·lyt′ic (-nə-lĭt′ĭk) adj.

fibrinolysis

[fī′brinol′isis]
the process of fibrin digestion by plasmin that is the normal mechanism for the removal of fibrin clots. It is stimulated by adhesion of plasmin and tissue plasminogen activator to fibrin. fibrinolytic, adj.

fi·bri·nol·y·sis

(fī'bri-nol'i-sis)
Hydrolysis of fibrin.
[fibrino- + G. lysis, dissolution]

fibrinolysis

The use of drugs to dissolve blood clots in the circulation. Enzymes such as streptokinase or urokinase, which break down FIBRIN, are used. A combination of fibrinolysis and aspirin, given soon after a coronary attack, greatly improves the chances of survival.

Fibrinolysis

The clot dissolving portion of the coagulation process.
Mentioned in: Fibrin Split Products

fibrinolysis

hydrolysis of fibrin; i.e. initiation of blood clot dissolution

fi·bri·nol·y·sis

(fī'bri-nol'i-sis)
Hydrolysis of fibrin.
[fibrino- + G. lysis, dissolution]

fibrinolysis

(fī´brinol´isis),
n the continual process of fibrin decomposition during the removal of small fibrin clots by the action of enzyme fibrinolysin.

fibrinolysis

the dissolution of fibrin by enzymatic action.

pathological fibrinolysis
see primary fibrinolysis (below).
primary fibrinolysis
occurs with an excess of activators or decreased plasma inhibitors that cause hyperplasminemia, as in severe liver disease, heat stroke and malignancy.
secondary fibrinolysis
is a response to the widespread formation of microthrombi as in disseminated intravascular coagulation.
References in periodicals archive ?
The average concentrations of blood markers of fibrinolysis at baseline, immediately postexposure, and 20 hr postexposure are presented in Supplemental Material, Table S4.
A novel hemostasis assay for the simultaneous measurement of coagulation and fibrinolysis.
Hypocoagulation stems from tissue injury, hypoperfusion, accelerated fibrinolysis, and increased inflammatory cascades.
Systemic fibrinolysis may be observed during absorption of ascites.
The attending doctor seeking advice from the senior doctor in the EC or the Internal Medicine registrar before commencing fibrinolysis.
In certain individuals, however, the balance between coagulation and fibrinolysis is disrupted due to the imposition of additional coagulatory stressors such as prolonged stasis, air flight, genetic predisposition, and use of estrogenic medications.
Alteplase is a tissue plasminogen activator enzyme that binds to fibrin in a thrombus and converts the plasminogen to plasmin, initiating fibrinolysis.
For the few patients whose cocaine-associated chest pain is caused by ST-segment elevation MI, percutaneous coronary intervention clearly is preferable to fibrinolysis.
No alteration in the PFA-100 in vitro bleeding time induced by the Ginkgo biloba special extract, Egb 761, in elderly patients with mild cognitive impairment," Blood Coagul Fibrinolysis, 2005.
The hypercoagulability associated with systemic inflammation is due primarily to an increase in procoagulant functions, an inhibition of fibrinolysis, and a downregulation of the three major physiologic anticoagulant systems (activated protein C/APC, antithrombin/AT, tissue factor pathway inhibitor/TFPI, Figure 1):
ExTRACT-TIMI 25 (Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment, Thrombolysis in Myocardial Infarction -- Study 25) trial showed that in patients with STEMI treated with fibrinolysis, at one year, the primary endpoint of death or nonfatal myocardial infarction remained significantly in favor or enoxaparin vs UFH (15.