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fibrinoid necrosis

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fibrinoid necrosis
'Smudgy' eosinophilic fibrin-like deposits, of degenerated collagen or ground substance, in arterial walls of Pts with malignant HTN and periarteritis nodosa; FN may also occur in the Arthus reaction, acute rheumatic fever, SBE, near peptic ulcers, rheumatoid arthritis, immune complex disease, HBV, malignancy, complement C2 deficiency, Henoch-Schönlein purpura, SLE and other collagen vascular diseases. See Fibrosis, Necrosis.


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The dura may demonstrate inflammation with fibrinoid necrosis (6).
Biopsy results positive for Winkler's disease include epithelial hyperplasia, collagen degeneration, focal fibrinoid necrosis, and inflammatory cells with or without cartilage degeneration.
The surface is ulcerated and covered by fibrin and/ or fibrinoid necrosis overlying an exuberant granulation tissue.
 
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