fibrinogen


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Related to fibrinogen: Fibrinogen Test

fibrinogen

 [fi-brin´o-jen]
a high-molecular-weight protein in the blood plasma that by the action of thrombin is converted into fibrin; called also factor i. In the clotting mechanism, fibrin threads form a meshwork for the basis of a blood clot. Most of the fibrinogen in the circulating blood is formed in the liver. Normal quantities of fibrinogen in the plasma vary from 100 to 700 mg per 100 ml of plasma.

Commercial preparations of human fibrinogen are used to restore blood fibrinogen levels to normal after extensive surgery, or to treat diseases and hemorrhagic conditions that are complicated by afibrinogenemia.
fibrinogen degradation products fragments of fibrinogen or fibrin degraded by plasmin, which are found in the serum and urine of patients with disseminated intravascular coagulation (DIC) and in the urine of patients who have had renal transplants.

fi·brin·o·gen

(fī-brin'ō-jen),
A globulin of the blood plasma converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and is defective in dysfibrinogenemia.

fibrinogen

/fi·brin·o·gen/ (fi-brin´o-jen) coagulation factor I.

fibrinogen

(fī-brĭn′ə-jən)
n.
A protein in the blood plasma that is essential for the coagulation of blood and is converted to fibrin by the action of thrombin in the presence of ionized calcium.

fi′bri·nog′e·nous (fī′brə-nŏj′ə-nəs) adj.

fibrinogen

[fībrin′əjən]
Etymology: L, fibra, fiber; Gk, genein, to produce
a plasma protein that is converted into fibrin by thrombin in the presence of calcium ions. Also called factor I. Compare fibrin. See also afibrinogenemia, blood clotting, fibrinolysis, thrombin.

fibrinogen

Coagulation factor I, factor I Hematology A soluble 340 kD plasma glycoprotein required for normal platelet function and wound healing; it is converted into fibrin in the common pathway of coagulation, and provides physical scaffolding for permanent hemostatic plugs, which is orchestrated under thrombin's baton; fibrinogen is an 'acute phase reactant,' which may be markedly ↑ in various types of nonspecific stimuli–eg, inflammation, hemostatic stress, pregnancy, autoimmune diseases; it is ↑ in hyperfibrinogenemia; ↓ in afibrinogenemia

fi·brin·o·gen

(fī-brin'ō-jen)
A globulin of the blood plasma that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; absent in afibrinogenemia and defective in dysfibrinogenemia.

fibrinogen

A protein in the blood that is converted to FIBRIN by the action of THROMBIN in the presence of ionized calcium, thereby bringing about coagulation of blood.

fibrinogen

or

fibrin

a large, soluble protein found in BLOOD PLASMA that is formed in the liver and is converted to insoluble fibrin by the enzyme thrombin during the process of BLOOD CLOTTING.

Fibrinogen

A type of blood protein called a globulin that interacts with thrombin to form fibrin.
Mentioned in: Prothrombin Time

fibrinogen

factor I; soluble plasma protein; converted by coagulation factor cascade into insoluble fibrin

fi·brin·o·gen

(fī-brin'ō-jen)
A globulin of blood plasma converted into fibrin by action of thrombin in presence of ionized calcium to coagulate blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and defective in dysfibrinogenemia.

fibrinogen

(fībrin´əjən)
(factor I, profibrin),
n a soluble plasma protein (globulin) that is acted on by thrombin to form fibrin. The normal level is 200 to 400 mg/100 ml in plasma. Coagulation is impaired if the concentration is less than 100 mg/100 ml. Another form called
tissue fibrinogen, which has the power of clotting the blood without the presence of thrombin, occurs in body tissues.

fibrinogen

a high-molecular-weight protein in the blood plasma that by the action of thrombin is converted into fibrin; called also clotting factor I. In the clotting mechanism, fibrin threads form a meshwork for the basis of a blood clot. Most of the fibrinogen in the circulating blood is formed in the liver. Elevations in the blood are nonspecific indicators of inflammatory disease.

fibrinogen deficiency
may be due to afibrinogenemia, hypofibrinogenemia or dysfibrinogenemia.
fibrinogen degradation products (FDPs)
see fibrin-fibrinogen degradation products.
fibrinogen split products
see fibrin-fibrinogen degradation products.

Patient discussion about fibrinogen

Q. What Are the Risk Factors for Developing Stroke? My father had a stroke recently, at the age of 73. What are the risk factors for developing this?

A. Primary risk factors include:

1) smoking
2) excessive alcohol intake
3) uncontrolled high blood pressure
4) high cholesterol
5) overweight/unhealthy diet
6) illegal drugs/abuse of Rx drugs
7) known or unknown heart problems
8) diabetes
9) known or unknown vascular brain defects - aneurysm, etc.
10)family history of stroke

Q. Regarding risk-factor assessment? Hello, I am……….., I heard ACSM has recently issued a new edition of its exercise guidelines. Were any changes made regarding risk-factor assessment?

A. Are you fitness professional? I understand that you are very much interested in food guidelines. It can be difficult to keep up with the latest guidelines and standards. This is particularly true this year, which has seen new USDA Food Guidelines in January, a revised Food Pyramid in May and, most recently, the release of the 7th edition of ACSM’s Guidelines for Exercise Testing and Prescription. The good news is that the ACSM risk factors have been minimally revised. For your reference, here is a summary of what has and has not changed for the 2006 edition.

Q. Is obesity a risk factor for Dementia?

A. The answer is YES. In fact, many of the risk factors for heart disease, such as high blood pressure, blood glucose levels, insulin resistance, and overweight, are also risk factors for dementia, in addition to genetic predisposition for the disease.

More discussions about fibrinogen
References in periodicals archive ?
On the other hand, fibrinogen appears to be associated with microangiopathy, particularly nephropathy.
After three months of taking three tablets a day, my fibrinogen dropped only from 408 to 401.
Pharming has obtained access to processes and know-how for the large scale GMP grade purification of recombinant fibrinogen.
The thrombin time is the time needed for thrombin to convert fibrinogen to an insoluble fibrin clot.
The mechanism of acquired dysfibrinogenemia involves increased sialylation of carbohydrate side chains of the fibrinogen molecule.
Plasma fibrinogen levels were determined using commercial kits on a STA compact autoanalyzer (STA, France).
The fibrinogen finding makes perfect sense," says Stephanie Eisenbarth, a physician and immunologist at Yale University.
Importantly, the team found a strategy to halt this process by genetically modifying fibrinogen in the animal models.
Each participating laboratory was asked to perform fibrinogen activity assays according to its local method and to report the assayed values and method used to the College of American Pathologists.
1) Most coagulation proteins, including fibrinogen, are synthesized by the liver; therefore, acquired dysfibrinogenemia may be present in chronic liver disease, or liver malignancies such as hepatocellular carcinoma.
In this issue of Clinical Chemistry, Lovely and colleagues (1) report an evaluation of a new plasma fibrinogen assay for the study of its associations with cardiovascular disease.

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