In work with Joel Buxbaum, experimental models of amyloidosis were studied, focusing on the mechanism of fibrillogenesis
According to the company, Decorinyl regulates fibrillogenesis
, controls collagen fibril growth and increases skin suppleness, due to a better cohesion of collagen fibers that provides higher resiliency and improves skin appearance.
We are interested in the repair (3 weeks) and early remodeling (6 weeks) phases, in which fibroblast proliferation, fibrillogenesis
and fibril remodeling are most active (Enwemeka, 1989; Oakes, 1994).
These 2 components play a major role in collagen fibrillogenesis
, homeostasis, and tissue development.
Small leucine-rich proteoglycans (SLRPs) are ECM proteoglycans required for collagen fibrillogenesis
Following implantation, the RPC Pure-Collagen reacts with local tissue and fibrillogenesis
is initiated to convert the collagen solution into a fiber matrix.
Lumican is a proteoglycan expressed in extracellular matrix (ECM) and connective tissues where it has been reported to contribute to collagen fibrillogenesis
, tissue hydration, migration and proliferation.
This model was used to determine the onset of amyloid-induced inflammation in the brain during the process of amyloid fibrillogenesis
Enhancement of fibronectin fibrillogenesis
and bone formation by basic fibroblast growth factor via protein kinase c-dependent pathway in rat osteoblasts.
Thermal stability and fibrillogenesis
of collagen from tissue of patients with Dupuytren's disease.
2]M is associated with senile plaques (3), binds to A[beta] peptide, the major component of [beta]-amyloid (4); attenuates fibrillogenesis
and neurotoxicity of A[beta] (4,5); and mediates A[beta] degradation (6,7).
2]M binds to the amyloid [beta] peptide (2, 3), which leads to attenuation of both fibrillogenesis
and neurotoxicity (4) and which is cleared by the LDL receptor-related protein.