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fibrillin

   Also found in: Acronyms, Wikipedia 0.03 sec.
Fibrillin
A protein that is an important part of the structure of the body's connective tissue. In Marfan's syndrome, the gene responsible for fibrillin has mutated, causing the body to produce a defective protein.
Mentioned in: Marfan Syndrome

fibrillin
[fibri′lin]
Etymology: L, fibrilla, small fiber
a major component of elastin-associated microfibrils. It is linked to Marfan's syndrome by findings of immunohistochemical studies and is associated with arachnodactyly, a disease similar to Marfan's syndrome.


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Among the topics are cadherins, adherens junctions and desmosomes, integrins and focal contacts, receptor tyrosine phosphatases, Notch and Slit-Robo signaling, adhesive binding to collagen and fibrillin, and complex adhesive mechanisms involved in leukocyte migration and malaria.
The mRNA of decorin was also stimulated, but elastin, and fibrillin 1 and 2 were not modified by the vitamin.
Fibrillin plays an important part in the normal structure or 'scaffolding' of connective tissue throughout the body.
 
 
 
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