fibrillary astrocytoma


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Related to fibrillary astrocytoma: protoplasmic astrocytoma

fi·bril·lar·y as·tro·cy·to·ma

astrocytoma derived from fibrillary astrocytes.

fibrillary astrocytoma

A relatively slow growing astrocytoma histologically composed of cells with many fibrils. It usually is found in adolescents and young adults. Although its cells are moderately well differentiated, they tend to invade neighboring tissues.
See also: astrocytoma
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5,48] To date, there are no molecular markers to identify potentially, or imminently, anaplastic phenotypes within the diffuse fibrillary astrocytoma group.
4] This important distinction highlights the fact that pilocytic astrocytomas (WHO grade 1) and diffuse fibrillary astrocytomas (WHO grade 2) are fundamentally different entities.
We now demonstrate that [Beta]III is a potential marker of high-grade astrocytomas, and its expression may also define incipient anaplastic phenotypes in diffuse fibrillary astrocytomas.
The cases were grouped into high-grade astrocytomas (consisting of anaplastic astrocytoma, WHO grade 3, and glioblastoma multiforme, WHO grade 4); diffuse fibrillary astrocytomas (including gemistocytic astrocytomas, WHO grade 2); and pilocytic astrocytomas (WHO grade 1).
In diffuse fibrillary astrocytomas, the distribution of [Beta]III immunoreactivity was also substantially less than that in high-grade astrocytomas (MLI, 4%; IQR, 0.
In contrast, [Beta]III immunoreactivity was present to a lesser extent in diffuse fibrillary astrocytomas (WHO grade 2) and was rarely detectable in pilocytic astrocytomas (WHO grade 1).