induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys.
One group also received TriCor, an Abbott Laboratories medicine to lower the blood fat triglycerides and raise good HDL cholesterol that belongs to a class of drugs called fibrates
All-cause mortality was slightly lower in people who took statins or fibrates
, compared with nonusers (HR, 0.
and niacin are not proven to lower cardiovascular disease risk/mortality in adults, and statins may indeed be diabetogenic.
are widely used for the treatment of hypertriglyceridemia and generally well tolerated (2,3).
and future PPARalpha agonists in the treatment of cardiovascular disease.
The second case involves people with type 2 diabetes who take fibrates
, drugs often used along with statins to treat high cholesterol.
Statins and fibrates
are the drugs usually prescribed to those with high cholesterol levels, and both are effective in achieving this objective.
The therapy chapters include discussion of such topics as treatment guidelines, exercise and lipids, weight loss, statins, bile acid sequestrants, cholesterol absorption inhibitors, nicotinic acid, fibrates
, endocannabinoid receptor blockers, modulation of biomarkers of inflammation, invasive imaging modalities and atherosclerosis, and noninvasive imaging modalities.
There were 30,241 filled prescriptions for cholesterol-lowering drugs during the study; 92% were for statins and 8% for non-statins, including fibrates
, bile acid-binding resins, or nicotinic acid and derivatives.
Diet may be helpful, while fibrates
may have a paradoxical effect on the cholesterol level.
A number of lipid lowering drugs are available to combat high cholesterol levels and include statins, anion exchange resins and fibrates