fibrate


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Related to fibrate: niacin, Fenofibrate, ezetimibe, statin

fibrate

(fī-brāt),
An alternate term for fibric acid derivatives used to treat hyperlipidemia.

fibrate

(fi'brat?)
Any of a class of carboxylic acid compounds commonly used as lipid-lowering medications, including gemfibrozil and fenofibrate, that primarily reduce levels of triglycerides. Medications of this class have a minor impact on low-density and high-density lipoprotein cholesterol.
Synonym: fibric acid derivative

fibrate

One of a class of drugs capable of lowering the levels in the body of lipids (fats) including cholesterol. Fibrates can reduce low-density lipoproteins and raise high density lipoproteins. Some act by interfering with cholesterol synthesis in the liver others by promoting the more rapid breakdown of lipoproteins.
References in periodicals archive ?
To assess the effects of statin and fibrate therapies on incident cardiovascular events in an elderly population, the investigators analyzed data from an ongoing cohort study of vascular disease among elderly residents of Bordeaux, Dijon, and Montpellier.
Ginsberg said the data should ease some safety concerns of adding a fibrate to statin therapy.
Indeed, fibrate drugs were developed using rodent models to treat hyperlipidemia in humans before the receptor was identified.
consider taking statins, niacin, or a fibrate drug, depending on your triglycerides and your other risk factors.
Liver enzyme elevations occur more frequently when either niacin or a fibrate is combined with a statin drug, and these enzyme levels should be checked more frequently in patients on this combination.
Another group in which fibrate therapy might be reasonably considered are those with a triglyceride level above 200 mg/dL and an HDL level below 35 mg/dL.
Abbott's TriLipix is part of a class of drugs called fibrates that raise "good" HDL cholesterol while reducing triglycerides and "bad" LDL cholesterol.
Treatment of hypertriglyceridaemia should include lifestyle changes, exclusion and control of secondary factors and fibrate therapy.
LCP-AtorFen, the combination of one of the most potent and safe statins (atorvastatin) plus a safe and efficacious fibrate (fenofibrate), opens the opportunity to address all angles of the atherogenic triad (LDL-C, HDL-C and Triglycerides) in one single pill", said Dr.
When Baycol was used with a triglyceride-lowering drug--a fibrate named gemfibrizol--the rhabdomyolysis rate skyrocketed to more than one case per year for every 10 people treated.
44) Because of its LDL cholesterol-lowering effect, therefore, fenofibrate may be the fibrate of choice for combination therapy with statins in the treatment of patients with HIV-associated dyslipidemia.