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alata leaves at the oral doses of 250, 500 and 1000 mg/kg body weight on daily basis from days 10 until day 18 post-coitum exhibited several potential effects on the maternal and fetal outcomes of pregnant rats (anti-implantation, anti-gonadotropic, anti-progesteronic, selective estrogenic, embryonic resorption and fetotoxic activities), but it could not induce abortion in the animals.
Fetotoxic potentials of Globularia arabica and Globularia alypum (Globulariaceae) in rats.
Others are potentially carcinogenic, including cobalt and vanadium, and still more are fetotoxic (harmful to fetuses), including aluminum, copper, barium, lead, and manganese.
They also had prenatal co-exposure to the fetotoxic pesticide chlorpyrifos (Whyatt et al.
Zileuton and zafirlukast should be avoided during pregnancy because they are teratogenic or fetotoxic in animals.
Albendazole (Albenza) is embryotoxic, fetotoxic, and teratogenic in rabbits and rats at doses less than the recommended human dose.
In a 2-year rat study, 31 mg/kg bw flusilazole induced Leydig cell tumors of the testis; flusilazole was fetotoxic and embryotoxic at [greater than or equal to] 9 mg/kg bw in a developmental study.
In rats, hexaconazole was fetotoxic at [greater than or equal to] 25 mg/kg bw.
Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice.
Exposure to pesticides was analyzed for two windows: preconception, the 4-month period from 3 months before conception to the calendar month of conception (consistent with potential sperm-mediated effects); and postconception, the 3-month period from the first calendar month after conception to the end of the first trimester (consistent with a fetotoxic effect).
There are no published data on zileuton (Zyflo) use in humans, but the drug should be avoided because it has been found to be teratogenic and fetotoxic in animals.