fetoprotein


Also found in: Dictionary, Thesaurus.

fetoprotein

(fē′tə-prō′tēn, -tē-ĭn)
n.
Any of several antigens normally present in a fetus and occurring abnormally in adults as a result of certain cancers or diseases of the liver.

fetoprotein

[-prō′tēn]
Etymology: L, fetus + Gk, proteios, first rank
an antigen that occurs naturally in fetuses and occasionally in adults as the result of certain diseases. An increased amount of alpha-fetoprotein in the fetus is diagnostic for neural tube defects. The presence of beta-fetoprotein in the blood of adults is associated with leukemia, hepatoma, sarcoma, and other neoplasms.

fe·to·pro·tein

, alpha (α)-fetoprotein (AFP) , gamma (γ)-fetoprotein , beta (β)-fetoprotein (fē'tō-prō'tēn, al'fă, gam'ă, bātă)
Fetal proteins found in small amounts in adults in the following forms: 1) AFP increases in maternal blood during pregnancy; when detected by amniocentesis, is an important indicator of neural tube defects (e.g., spina bifida); used as a tumor marker in adults with hepatocellular carcinoma; 2) beta (β)-fetoprotein, although a fetal liver protein, has been detected in adult patients with liver disease; and 3) gamma (γ)-fetoprotein occurs in association with various neoplasms.
See also: fetoglobulins

fetoprotein

(fe?to-pro'ten)
An antigen present in the human fetus and in certain pathological conditions in adults. The amniotic fluid level can be used to evaluate fetal development. Elevated serum levels are found in adults with certain kinds of liver diseases.
See: alpha-fetoprotein
References in periodicals archive ?
Special staining demonstrated that only a very few tumor cells were positive for alpha fetoprotein, despite the markedly elevated level of alpha fetoprotein in her serum.
Markedly elevated serum alpha fetoprotein levels facilitated the diagnosis.
Laboratory studies revealed that her serum alpha fetoprotein level was 7,020 ng/ml (normal: 0-10).
Only a very few tumor cells showed strong alpha fetoprotein positivity.
Clinically, the patient experienced a complete resolution of her facial nerve palsy (figure 6), and her serum alpha fetoprotein levels returned to normal (4.
The determinant points were the elevated serum alpha fetoprotein level, the histology of the tumor, and the dramatic response to triple-drug chemotherapy.
None of these tumors has been associated with elevated serum alpha fetoprotein levels.
Although only a very few tumor cells were positive for alpha fetoprotein, the serum alpha fetoprotein level was markedly elevated.
Most surprising was the finding that patient demographics influenced both des-gamma-carboxy prothrombin and alpha fetoprotein values, but in opposite directions," said Lok, who also is the University of Michigan's Alice Lohrman Andrews Research Professor in Hepatology.
The three cancer markers are Id1, HMGA2 and Alpha Fetoprotein.
alpha fetoproteins or carcinoembryonic antigens) in these lesions.