Introduction of Doppler ultrasound in obstetrics allows us to study the changes in uteroplacental and fetoplacental
circulation in adverse conditions like PIH.
Given that maternal serum PSA concentrations are increased in pregnancy and that many products of the fetoplacental
unit have abnormal concentrations in Down syndrome pregnancy, we hypothesized that maternal serum PSA concentrations are also abnormal in Down syndrome pregnancy.
Doppler is a rapid noninvasive test to know the hemodynamic condition of the fetoplacental
Circumference of cord were measured in three areas-maternal end, middle & fetal end by using thread, coiling index and fetoplacental
ratio was calculated.
As fetal growth within uterus is influenced by genetic, epigenetic, environmental factors and maternal maturity, fetoplacental
resistance through deficiency of nutrients and oxygen from mother to fetus and altered endocrine status results in fetoplacental
resistance and vasodilator deficiency ie.
In a normal pregnancy, resistance to blood flow decreases in the uterine artery, which facilitates perfusion of the fetoplacental
unit (Mose 2014).
He studied that both the uteroplacental and fetoplacental
circulations are usually low resistance systems.
Abnormalities in maternal circulation (maternal vascular malperfusion) can lead to fetoplacental
unit underperfusion and FVM.
Conclusions: Findings suggest that elevated exposures to the fetoplacental
stress signal pCRH exert programming effects on the developing fetal central nervous system, with lasting consequences for child mental health.
In cases of isolated uteroplacental insufficiency (UPI) without fetoplacental
insufficiency (FPI), 93% (n = 15) survived.
Recent studies have highlighted the potential importance of epigenetic effects on the regulation of placental gene expression, particularly in the contexts of fetoplacental
development, trophoblast differentiation, fetal programming, and placental pathophysiology.
Aspects of human fetoplacental
vasculogenesis and angiogenesis.