Despite the induction by atrazine of CYP19 activity in H295R cells (the fetal compartment), estradiol and estriol production by the co-culture (the cooperative fetoplacental
unit) was not altered, indicating that the contribution of "fetal" CYP19 to overall estrogen production is small, if not negligible, in our co-culture model, as it is in the human fetoplacental
unit in vivo.
Kosanke G, Kingdom J, Kaufmann P Increased fetoplacental
angiogenesis during first trimester in anaemic women.
Furthermore, the results are also not consistent with previous studies on maternal smoking that reported increased uteroplacental and fetoplacental
resistance in smokers compared with nonsmoking mothers (Geelhoed et al.
If bleeding: calculate Hb deficit from volume/expected fetoplacental
volume, check mca vmax
The relatively low oxygen environment in which the human fetoplacental
unit develops during the first trimester is necessary to induce vasculoangiogenesis via embryonic endothelial cells proliferation, as these cells are sensitive to hypoxia and acidosis," Dr.
vascular bed serves as a means of transport of nutrients and metabolites from placenta to fetus and vice versa.
These findings gave rise to the developmental origins of health and disease model, where "causes to be identified are linked to normal variations in fetoplacental
and infant development" (Barker 2012).
In one study of 12 fetuses expansion of fetoplacental
blood volumes ranged from 36.
growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation.
Additionally, the risk of stillbirth caused by fetoplacental
dysfunction increases as alcohol consumption increases (8.
Morphometric evidence that villous development and fetoplacental
angiogenesis are compromised by intrauterine growth restriction but not by pre-eclampsia.
These can all affect the mother, fetus and fetoplacental
unit in general.