The positive archival samples comprised 5 bone marrow aspirates from anemic patients whose blood previously tested positive for B19 DNA by PCR-ELISA, 5 amniotic fluid cell samples from patients with fetal hydrops whose amniotic fluid previously tested positive for B19 DNA by PCR-ELISA, and 3 paraffin-embedded liver biopsy sections from transplant recipients whose biopsy lysates previously tested positive for B19 DNA by PCR-ELISA.
Of the 5 amniotic fluid cell samples that previously tested positive for B19 DNA by PCR-ELISA from patients with a clinical diagnosis of B19 fetal hydrops, all were positive in the B19 PNA-ISH assay, whereas only 2 samples were positive in the DNA-ISH assay (see Table 1 in the online Data Supplement).
They may even present in utero, causing nonimmune fetal hydrops
B19 parvovirus, in fact, is a widespread virus that can cause acute diseases, such as erythema infectiosum, fetal hydrops
, postinfectious arthropathy, and transient aplastic crises; it also can cause chronic infections that can occur with very low blood viral titers (10).
The treatment resulted in successful in utero conversion to normal sinus rhythm in 82% of the cases, including 80% of those with fetal hydrops
Trisomy 21, fetal hydrops
, and anemia: perinatal diagnosis of transient myeloproliferative disorder?
These findings include any extracardiac malformation, the presence of fetal hydrops, omphalocele, diaphragmatic hernia, duodenal atresia, nuchal edema, single umbilical artery tracheoesophageal fistula, and cystic hygroma.
Most fetuses with cardiac anomalies can be delivered vaginally The few exceptions are those with fetal hydrops, congenital heart block, or arrhythmia; these conditions make it very difficult to monitor the fetus' well-being during labor.
This growth should be monitored because it can lead to cardiac compromise and fetal hydrops
requiring early delivery.
There were no cases of fetal hydrops
, neonatal anemia, or thrombocytopenia, and none of the newborns were small for gestational age.