Our laboratory has shown that introducing the beneficial mutation British-198 into blood cells using this technology substantially boosts their production of fetal hemoglobin
The influence of fetal hemoglobin
on the clinical expression of sickle cell anemia.
We have been able to snip that DNA target using CRISPR, remove a short segment in a control section of DNA that stimulates gamma-to-beta switching, and join the ends back up to produce sustained elevation of fetal hemoglobin
levels in adult red blood cells.
Fung, "Cucurbitacin D induces fetal hemoglobin
synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the [gamma]-globin mRNA," Blood Cells, Molecules, and Diseases, vol.
Expression of fetal hemoglobin
in adult humans exposed to high altitude hypoxia, Blood Cells Mol Dis.
The flow cytometry laboratories using the Technical Manual calculation had a much narrower range of results for the percentage of fetal hemoglobin
This one is a major player," Orkin said, calling BCL11A a "silencer gene" responsible for keeping fetal hemoglobin
Coverage includes salivary biomarkers, tumor markers in pseudopodia for invasive migration, intraocular lymphoma markers, serum tumor markers in breast cancer, diagnostic classification using gene expression profiling in AML, tumor antigens as markers of minimal residual disease in acute myeloid leukemia, activity and expression of dipeptidyl peptidase IV and cathepsin H in human cutaneous melanoma compared to other common cancers, ovarian cancer detection, comparison of the prognostic association of nucleolar size between uveal and conjunctival melanoma, biomarkers of hepatocellular carcinoma, cell adhesive markers in metastasizing colorectal carcinoma, and fetal hemoglobin
as an oncofetal marker.
Hemoglobinopathies are a heterogeneous group of congenital defects involving the hemoglobin variants, thalassemias and hereditary persistence of fetal hemoglobin
Over the years of treating cancer, clinicians and researchers observed that many anticancer drugs increase fetal hemoglobin
In one case series of 233 adult patients who were followed up after 9 years, the investigators found a 40% reduction in mortality with the drug, a cytotoxic agent that increases fetal hemoglobin
and decreases sickle cell hemoglobin.
Bhattacharya, A study report of 174 units of placental umbilical cord whole blood transfusion in 62 patients as a rich source of fetal hemoglobin
supply in different indications of blood transfusion, Clinical and Experimental Obstetrics and Gynecology, Vol.