fetal hemoglobin


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Related to fetal hemoglobin: Fetal Hemoglobin Test, Hereditary Persistence of Fetal Hemoglobin

he·mo·glo·bin F

[MIM*142200]
normal fetal Hb (Hb F) of molecular formula α2Aγ2F, which is the major Hb component during intrauterine life, decreasing rapidly during infancy to reach a concentration of less than 0.5% in normal children and adults; the concentration of Hb F is increased in some hemoglobinopathies and in some cases of hypoplastic anemia, pernicious anemia, and leukemia; Hb F has a weaker affinity for 2,3-bisphosphoglycerate than does Hb A. More than 50 mutant variants of the γ chain have been reported.
Synonym(s): fetal hemoglobin

fetal hemoglobin

n.
The predominant form of hemoglobin in fetuses and newborn infants, present in small amounts in adults but often elevated in adults with certain forms of anemia and other disorders.

fetal hemoglobin

hemoglobin F, the major hemoglobin present in the blood of a fetus and neonate. Hemoglobin F is present in only trace amounts in the blood of normal adults.

fetal hemoglobin

Hemoglobin F An immature Hb composed of 2 α and 2 γ chains that usually disappears in the neonatal period. See Hereditary persistence of fetal hemoglobin.
References in periodicals archive ?
High HbF is a circulating fetal hemoglobin that affects 1.
Hereditary persistence of fetal hemoglobin (HPFH) is a state in which the pattern of hemoglobin production of the unborn child continues into adult life.
of Acetylon during an ASH poster session today in a poster titled, "Induction of Human Fetal Hemoglobin Expression by Selective Inhibitors of Histone Deacetylase 1 and 2 (HDAC1/2).
Agreement between HbA1c measured by DCA 2000 and by HPLC: effects of fetal hemoglobin concentrations.
Likewise, increases in fetal hemoglobin percentage in adults with disease states such as thalassemias are fairly common, and hereditary states of persistence of fetal hemoglobin in adult life are described, which could also (rarely) confound a Kleihauer-Betke test.
Increasing fetal hemoglobin increases total hemoglobin while decreasing hemolysis and vaso-occlusion.
urtalama kirmizi kan hucresi hacminin buyuklugu ve fetal hemoglobin (HbF) oraninin yuksekligi.
2]), the gamma chain of fetal hemoglobin ([[alpha].
It also has the advantage of a higher oxygen carrying capacity of fetal hemoglobin in addition to many growth factors and other cytokine filled cord blood plasma along with its hypoantigenicity.
This overview includes descriptions of leukemia/lymphoma immunophenotyplng, human immunodeficiency virus monitoring, reticulocyte counting, platelet analysis, stem cell enumeration, and fetal hemoglobin analysis.
The presence of high levels of fetal hemoglobin (HbF) in red blood cells decreases the severity of clinical manifestations associated with sickle cell disease.
He believes that the fetal hemoglobin adducts serve as markers of the number of DNA adducts that smoking creates in the fetus.