fetal hemoglobin


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he·mo·glo·bin F

[MIM*142200]
normal fetal Hb (Hb F) of molecular formula α2Aγ2F, which is the major Hb component during intrauterine life, decreasing rapidly during infancy to reach a concentration of less than 0.5% in normal children and adults; the concentration of Hb F is increased in some hemoglobinopathies and in some cases of hypoplastic anemia, pernicious anemia, and leukemia; Hb F has a weaker affinity for 2,3-bisphosphoglycerate than does Hb A. More than 50 mutant variants of the γ chain have been reported.
Synonym(s): fetal hemoglobin

fetal hemoglobin

n.
The predominant form of hemoglobin in fetuses and newborn infants, present in small amounts in adults but often elevated in adults with certain forms of anemia and other disorders.

fetal hemoglobin

hemoglobin F, the major hemoglobin present in the blood of a fetus and neonate. Hemoglobin F is present in only trace amounts in the blood of normal adults.

fetal hemoglobin

Hemoglobin F An immature Hb composed of 2 α and 2 γ chains that usually disappears in the neonatal period. See Hereditary persistence of fetal hemoglobin.
References in periodicals archive ?
Our laboratory has shown that introducing the beneficial mutation British-198 into blood cells using this technology substantially boosts their production of fetal hemoglobin.
The influence of fetal hemoglobin on the clinical expression of sickle cell anemia.
We have been able to snip that DNA target using CRISPR, remove a short segment in a control section of DNA that stimulates gamma-to-beta switching, and join the ends back up to produce sustained elevation of fetal hemoglobin levels in adult red blood cells.
Fung, "Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the [gamma]-globin mRNA," Blood Cells, Molecules, and Diseases, vol.
Expression of fetal hemoglobin in adult humans exposed to high altitude hypoxia, Blood Cells Mol Dis.
The flow cytometry laboratories using the Technical Manual calculation had a much narrower range of results for the percentage of fetal hemoglobin (0.
Coverage includes salivary biomarkers, tumor markers in pseudopodia for invasive migration, intraocular lymphoma markers, serum tumor markers in breast cancer, diagnostic classification using gene expression profiling in AML, tumor antigens as markers of minimal residual disease in acute myeloid leukemia, activity and expression of dipeptidyl peptidase IV and cathepsin H in human cutaneous melanoma compared to other common cancers, ovarian cancer detection, comparison of the prognostic association of nucleolar size between uveal and conjunctival melanoma, biomarkers of hepatocellular carcinoma, cell adhesive markers in metastasizing colorectal carcinoma, and fetal hemoglobin as an oncofetal marker.
Hemoglobinopathies are a heterogeneous group of congenital defects involving the hemoglobin variants, thalassemias and hereditary persistence of fetal hemoglobin (HPFH).
Over the years of treating cancer, clinicians and researchers observed that many anticancer drugs increase fetal hemoglobin levels.
In one case series of 233 adult patients who were followed up after 9 years, the investigators found a 40% reduction in mortality with the drug, a cytotoxic agent that increases fetal hemoglobin and decreases sickle cell hemoglobin.
Bhattacharya, A study report of 174 units of placental umbilical cord whole blood transfusion in 62 patients as a rich source of fetal hemoglobin supply in different indications of blood transfusion, Clinical and Experimental Obstetrics and Gynecology, Vol.