ferruginous body

ferruginous body

A fibre clad in protein, mucopolysaccharides, and iron (hence the adjective ferruginous). While ferrugious bodies are classically associated with asbestos, fibres on which such bodies develop include other elongated fibres that cannot be digested by macrophages—e.g., aluminium, aluminium oxide, carbon, diatomaceous earth, kaolite, mica, mullite, iron, fibreglass, rutile, sheet silicates and talc.

Ferruginous body evaluation
• Light microscopy—Perl’s stain of routine paraffin sections; thick (20µ) unstained sections.
• Phase contrast light microscopy.
• Scanning electron microscopy.
• Transmission electron microscopy.

The finding of ferruginous bodies only proves exposure, not disease. In tumour cases, three blocks of tissue from the contralateral side should be taken.
References in periodicals archive ?
The iron-protein coating enveloping an asbestos core is called an asbestos body or ferruginous body.
Ferruginous body formation varies according to a number of factors including fiber type, length, concentration (fiber burden), quantity of iron within the lung, and other host factors.
An example of this Type C ferruginous body is shown in Figure 4.
There was a mixture of ferruginous body (FB) types found on the slides (Table 1).
There was one ferruginous body found by light microscopy, formed on a "flake-like" or plate material which had varying degrees of ferruginous deposits along its periphery.
There was one Type D ferruginous body which we determined was formed on aluminum silicates (Figure 10).
The second form of ferruginous body as defined by light microscopy had as its core a thin black filament determined by electron microscopy to be composed of amorphic organic material (Type B).
The final form of ferruginous body (Type D) was not confused with the other elongated forms of ferruginous bodies that occur on fibrous cores because the material comprising the cores in these entities were plates or "flake-like" structures, and often displayed a yellowish dark golden coloration.