ferroportin


Also found in: Wikipedia.

ferroportin

(fĕr″ō-pŏr′tĭn) [″ + L. portare, to carry]
An iron-transporting molecule that spans cell membranes in the upper gastrointestinal tract and many other organs. Excessive expression of ferroportin by cells can result in iron overload.
References in periodicals archive ?
There is some phenotypic variation with haemojuvelin, hepcidin or ferroportin mutations presenting at an earlier age.
Hepcidin then is not available to block iron transport through the ferroportin channel into the bloodstream.
Ferroportin and hepcidin, the original gene dyad they found, control iron export.
Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.
IL-6 impedes iron oscillation from body stores by down-regulating the expression of ferroportin as well.
65) (Type IV hereditary hemochromatosis, ie, ferroportin deficiency, results in diffuse and exclusively reticuloendothelial iron, but that genetic condition is not known to actually cause disease.
Evidence suggests that the pathophysiologic basis of excess iron absorption is due to high levels of expression of divalent metal transporter-1 that transports iron into enterocytes in the proximal intestine, and ferroportin that exports iron to the circulation.
hemochromatosis, hepcidin or ferroportin deficiency, [beta]-thalassemia, liver diseases, end-stage renal disease, diabetes, and myelodysplastic syndrome (1).
2004b) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.
Since hepcidin inhibits iron exportation from cells by blocking ferroportin activity, the root cause of the hypoferremia and iron-restricted erythropoiesis in ACD can be attributed to the excess hepcidin levels.
Hephaestin is a ceruloplasmin homolog, and colocalizes with ferroportin at the basolateral membrane of enterocytes.