ferroportin


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ferroportin

(fĕr″ō-pŏr′tĭn) [″ + L. portare, to carry]
An iron-transporting molecule that spans cell membranes in the upper gastrointestinal tract and many other organs. Excessive expression of ferroportin by cells can result in iron overload.
References in periodicals archive ?
Degradation of ferroportin also reduces iron release from macrophages.
sup][30] It is then exported by the ferroportin (FPN) to bind to transferrin in the bloodstream,[sup][31],[32] and taken to the erythroblasts for erythropoiesis.
Ferroportin mediates the intestinal absorption of iron from a nanoparticulate ferritin core mimetic in mice.
Inflammation up-regulates Hepcidin, the primary hepatic iron absorption regulating protein, which inhibits the activity of Ferroportin at the intestinal basolateral cell membrane to transport iron out of storage for utilization.
It is postulated therefore that, by downregulating hepcidin synthesis, E2 may maintain ferroportin integrity and enhance intracellular iron efflux.
If the hepcidin level is elevated because of systemic inflammation, it will deny entry to iron by upregulating ferroportin or direct the iron to be sequestered in macrophages.
Bioactive hepcidin is a 25-amino-acid hepatic peptide hormone controlling physiological iron homeostasis (1, 2) by causing degradation of the iron-exporter ferroportin, thereby inhibiting absorption of dietary iron from the gut and iron release from storage sites (3).
GDF15 - mediated upregulation of ferroportin plays a key role in the development of hyperferritinemia in children with hemophagocytic lymphohistiocytosis.
19] Pinnix ZK, Miller LD, Wang W DAgostino R Jr, Kute T, Willingham MC, et al Ferroportin and iron regulation in breast cancer progression and prognosis.
Hepcidin is also considered as a master regulator in the management of cellular iron homeostasis by binding to iron exporter protein ferroportin 1 (Fpn1) in cell membranes and causing its subsequent internalization and lysosomal degradation [3].
Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages.
Activation of M1 macrophages is associated with upregulation of iron storage protein H ferritin and reduction of ferroportin, leading to iron retention and inflammation [14].