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ferrochelatase

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.02 sec.
ferrochelatase
an enzyme involved in the incorporation of elemental iron into the hemoglobin synthesis cycle. Called also heme synthetase.


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Pb also interferes with the normal functioning of the intramitochondrial enzyme ferrochelatase, which is responsible for the chelation of iron by protoporphyrin.
We hypothesized that the different bioavailability of PbB determined by ALAD isotypes differentially affects ferrochelatase activity and therefore Hb synthesis.
1976) Pb Inhibition of ferrochelatase NOAEL: 25 [micro]g/dL resulting in accumulation of eryhrocyte protoporphyrin (Mushak et al.
 
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