fenofibrate


Also found in: Dictionary, Encyclopedia, Wikipedia.

fenofibrate

 [fen″o-fi´brāt]
an agent chemically related to clofibrate, used to treat hyperlipidemia; administered orally.

fenofibrate

Antara, Apo-Fenofibrate (CA), Fenogal (UK), Lipantil (UK), Lipofen, Lofibra, Nu-Fenofibrate (CA), Tricor, Triglide, Supralip (UK)

Pharmacologic class: Fibric acid derivative

Therapeutic class: Antihyperlipidemic

Pregnancy risk category C

Action

Inhibits triglyceride synthesis in liver, reducing levels of low- and very-low-density lipoproteins. Also increases uric acid secretion.

Availability

Capsules: 50 mg, 150 mg

Capsules (micronized): 43 mg, 67 mg, 130 mg, 134 mg, 200 mg

Tablets: 48 mg, 50 mg, 54 mg, 145 mg, 160 mg

Indications and dosages

Adjunct to dietary therapy to reduce elevated low-density lipoproteins (LDL)-C, total cholesterol, triglycerides, and apolipoprotein B; to increase high-density lipoprotein-C level in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Adults: 1 tablet (145 or 160 mg), 1 capsule (150 mg), or 1 micronized capsule (130 or 200 mg) P.O. daily

Hypertriglyceridemia

Adults: Initially, 50 to 150 mg P.O. daily (capsule); 43 to 200 mg P.O. daily (micronized capsule); 48 to 160 mg P.O. daily (tablet)

Dosage adjustment

• Renal impairment
• Elderly patients

Off-label uses

• Polymetabolic syndrome X

Contraindications

• Hypersensitivity to drug
• Hepatic disease or unexplained, persistent liver function test abnormalities
• Severe renal impairment
• Gallbladder disease
• Breastfeeding

Precautions

Use cautiously in:
• pancreatitis, cholelithiasis
• patients receiving warfarin concurrently
• pregnant patients
• children.

Administration

Before giving, be aware of potentially serious interactions, such as with nephrotoxic drugs.
• Administer with meals.
• Give bile acid sequestrants at least 1 hour before or 4 to 6 hours after fenofibrate.

Adverse reactions

CNS: drowsiness, dizziness, fatigue, headache, migraine, insomnia, depression, vertigo, nervousness, anxiety, paresthesia, hypotonia, neuralgia

CV: tachycardia, varicose veins, phlebitis, angina, hypertension, hypotension, peripheral vascular disease, vasodilation, ECG abnormalities, coronary artery disease, arrhythmias, ventricular extrasystoles, myocardial infarction, atrial fibrillation

EENT: conjunctivitis, abnormal vision, cataracts, refraction disorder, otitis media, rhinitis, sinusitis, pharyngitis, laryngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, flatulence, dyspepsia, gastritis, gastroenteritis, esophagitis, duodenal or peptic ulcer, colitis, cholelithiasis, cholecystitis, rectal disorder, rectal hemorrhage

GU: urinary frequency, dysuria, cystitis, urolithiasis, prostatic disorder, gynecomastia, vaginal candidiasis, decreased libido, renal dysfunction

Hematologic: eosinophilia, anemia, lymphadenopathy, thrombocytopenia, leukopenia

Hepatic: fatty liver deposits

Metabolic: hyperuricemia, gout, hypoglycemia

Musculoskeletal: back, muscle, or joint pain; myositis; arthritis; tenosynovitis; arthrosis; bursitis

Respiratory: respiratory disorders, bronchitis, increased cough, dyspnea, pneumonia, asthma

Skin: rash, pruritus, urticaria, bruising, acne, eczema, diaphoresis, dermatitis, herpes simplex, herpes zoster, alopecia, nail disorder

Other: weight loss or gain, edema, fever, flulike symptoms, hypersensitivity reactions

Interactions

Drug-drug.Bile acid sequestrants (resins): decreased absorption and efficacy of fenofibrate

Immunosuppressants, other nephrotoxic drugs: increased risk of renal toxicity

Oral anticoagulants: increased risk of bleeding

Statins (such as simvastatin): rhabdomyolysis, acute renal failure

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, creatinine, gamma-glutamyltransferase, uric acid: increased values

Granulocytes, hemoglobin, neutrophils, platelets, white blood cells (WBCs): decreased values

Liver function tests: abnormal results

Drug-food.Any food: increased drug absorption

Drug-behaviors.Alcohol use: elevated triglyceride level

Patient monitoring

• Assess creatine kinase and lipid levels and liver function test results.
• Monitor CBC and WBC count. Expect these to decrease at start of therapy, then stabilize.

Patient teaching

• Instruct patient to take with meals for best effect.
• Remind patient that he still needs to follow a triglyceride-lowering diet.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to minimize GI upset by eating frequent, small servings of food and drinking plenty of fluids.
• Tell patient that drug may take up to 2 months to alter lipid values.
• Inform breastfeeding patient that she must choose between taking fenofibrate and breastfeeding.
• Tell female patient to inform prescriber if she is pregnant.
• Inform patient that he'll undergo regular blood testing.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and behaviors mentioned above.

fenofibrate

/fen·o·fi·brate/ (fen″o-fi´brāt) an antihyperlipidemic agent used to reduce elevated serum lipids.

fenofibrate

[fen′ofi′brāt]
an agent chemically related to clofibrate used to treat hyperlipidemia, administered orally.

fenofibrate

Tricor®, Lipanthyl® An agent used to manage super-high serum TG levels uncontrolled by diet alone or in Pts at risk for pancreatitis

fenofibrate

A fibrate anticholesterol drug used to treat high blood cholesterol levels that fail to respond to diet modification. A brand name is Lipantil Micro.
References in periodicals archive ?
Fenofibrate Capsules 67mg, 134mg and 200mg are the generic version of Abbvie Inc's Tricor Micronized Capsules, 67mg, 134mg and 200mg.
In this report, we describe a patient who developed severe thrombocytopenia while on fenofibrate treatment.
The most commonly prescribed combination therapy was atorvastatin and fenofibrate, and was prescribed to a total of 13 patients enrolled in the study.
However a sub-analysis of the subgroups of more than 2000 patients with high TG (> 200 mg/dl) showed that fenofibrate significantly reduced CV events by 27% concluding that fenofibrate do reduce CV events in T2DM patients when the baseline TG are high.
In the ACCORD lipid study, patients were treated with simvastatin for 4 weeks, then randomized to continue treatment with simvastatin and placebo (2,753 patients) or simvastatin and fenofibrate (2,765 patients).
The trial was split between those receiving combination of a fenofibrate and simvastatin and those who received simvastatin alone.
She had taken 250 mg fenofibrate daily for almost 1 month because of her hyperlipidemia.
They also were assigned to undergo either intensive or standard control of systolic blood pressure (less than 120 mmHg or less than 140 mmHg, respectively) or to receive lipid control with simvastatin in combination with either fenofibrate or a placebo.
ATLANTA -- The failure to significantly reduce the cardiovascular event rate with fenofibrate treatment in a large trial of high-risk type 2 diabetes patients probably occurred because the study enrolled too many of the wrong types of patients to clearly show a benefit from this drug, several experts said.
The acquisition also includes global rights to the fenofibrate franchise; currently Abbott has U.
Summary: The anti-cholesterol drug fenofibrate appears to reduce risks of amputation for diabetics by as much as 36 percent, a study has found.