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fenfluramine

   Also found in: Wikipedia 0.01 sec.
fenfluramine /fen·flur·amine/ (fen-flldbomacr´ah-mēn) an amphetamine derivative, formerly used as an anorectic in the form of the hydrochloride salt.
fen·flu·ra·mine (fn-flr-mn)
n.
A fluorinated compound that is used in the treatment of refractory obesity.
fenfluramine
Pondimin®, Redux® Internal medicine An adrenergic appetite suppressing–anorectic amphetamine congener, which, unlike amphetamine, depresses the CNS; fenfluramine ↑ serotonin levels and imparts a sensation of fullness from a lower intake of food and was prescribed as a short-term adjunct in obesity; it was withdrawn from the market following its association with heart valve abnormalities and other cardiac complications Adverse effects Pulmonary HTN, attributed either to serotonic vasoconstriction or altered depolarization of pulmonary vascular smooth muscle membrane. See Fen/Phen.


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? Mentioned in ? References in periodicals archive
 
Wyeth marketed the dangerous "fen" half of it--the drugs fenfluramine and dexfenfluramine, sold under the brand names Pondimin and Redux.
Wyeth's comeback kid: Robert Essner guides the pharma giant back from ... by Hawthorne, Fran / Chief Executive (U.S.)
There was no difference in weight loss between the 11 participants who took the weight-loss drug fenfluramine and the 4 who received a placebo.
A toxic side of weight loss: pollutants may slow body's metabolism by Lock, C. / Science News
As a result of these reports, the manufacturer has voluntarily withdrawn two medications, fenfluramine (Pondimin) and dexfenfluramine (Redux) from the market.
Prescription Medications for the Treatment of Obesity by Pamphlet by: National Institute of Diabetes & Digestive & Kidney Diseases
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