fenfluramine


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fenfluramine

 [fen-flo̳r´ah-mēn]
an appetite suppressant used as the hydrochloride salt; unlike the amphetamines, it seems to depress rather than stimulate the central nervous system.

fenfluramine

/fen·flur·amine/ (fen-flldbomacr´ah-mēn) an amphetamine derivative, formerly used as an anorectic in the form of the hydrochloride salt.

fenfluramine

Pondimin®, Redux® Internal medicine An adrenergic appetite suppressing–anorectic amphetamine congener, which, unlike amphetamine, depresses the CNS; fenfluramine ↑ serotonin levels and imparts a sensation of fullness from a lower intake of food and was prescribed as a short-term adjunct in obesity; it was withdrawn from the market following its association with heart valve abnormalities and other cardiac complications Adverse effects Pulmonary HTN, attributed either to serotonic vasoconstriction or altered depolarization of pulmonary vascular smooth muscle membrane. See Fen/Phen.

fenfluramine

A drug used in the management of obesity. It is thought to work by producing a sense of having eaten enough (satiety) rather than by suppressing appetite. There is evidence that fenfluramine may be associated with heart valve disease and PULMONARY HYPERTENSION and it is now rarely used.
References in periodicals archive ?
Now, the researchers have defined a circuit in the brain that explains the ways fenfluramine, a component of Fen-phen, suppresses appetite.
However, since 1997, fenfluramine, dexfenfluramine and phenylpropanolamine have been removed from U.
While being told that their sons would undergo only a safe test to discover if they might have any medical problems, the children were instead subjected to doses of the drug fenfluramine (one of the components of the banned drug Fen-Phen).
Wyeth marketed the dangerous "fen" half of it--the drugs fenfluramine and dexfenfluramine, sold under the brand names Pondimin and Redux.
Ironically, the FDAMA was enacted only two months after the popular diet drugs fenfluramine and dexfenfluramine were withdrawn from the market because of adverse events linked to their off-label use.
In addition, certain medications, particularly diet pills such as Fen-Phen (a combination of fenfluramine and phentermine that was taken off the market several years ago) may cause this condition.
There was no difference in weight loss between the 11 participants who took the weight-loss drug fenfluramine and the 4 who received a placebo.
The Medicines and Healthcare Products Regulatory Agency (MHRA) banned the pills, which contain the illegal drugs Nitrosofenfluramine and Fenfluramine, which have been found to disintegrate the liver and the heart.
The pills contain the illegal drugs Nitrosofenfluramine and Fenfluramine, which have been found to disintegrate the liver and put dangerous pressure on the heart.
Tests later conducted by the government showed Slim 10 contained fenfluramine, a controlled substance under the Poisons Act and associated with heart-valve and thyroid problems.
Despite the fact that fenfluramine had enjoyed FDA approval for many years--a claim that no supplement product can ever make--the manufacturer was hammered by the plaintiffs' bar after the Mayo clinic published a small series of case reports hypothesizing that fenfluramine can damage users' heart valves, especially when used in combination with phentermine.