fenfluramine


Also found in: Dictionary, Wikipedia.

fenfluramine

 [fen-flo̳r´ah-mēn]
an appetite suppressant used as the hydrochloride salt; unlike the amphetamines, it seems to depress rather than stimulate the central nervous system.

fenfluramine

/fen·flur·amine/ (fen-flldbomacr´ah-mēn) an amphetamine derivative, formerly used as an anorectic in the form of the hydrochloride salt.

fenfluramine

Pondimin®, Redux® Internal medicine An adrenergic appetite suppressing–anorectic amphetamine congener, which, unlike amphetamine, depresses the CNS; fenfluramine ↑ serotonin levels and imparts a sensation of fullness from a lower intake of food and was prescribed as a short-term adjunct in obesity; it was withdrawn from the market following its association with heart valve abnormalities and other cardiac complications Adverse effects Pulmonary HTN, attributed either to serotonic vasoconstriction or altered depolarization of pulmonary vascular smooth muscle membrane. See Fen/Phen.

fenfluramine

A drug used in the management of obesity. It is thought to work by producing a sense of having eaten enough (satiety) rather than by suppressing appetite. There is evidence that fenfluramine may be associated with heart valve disease and PULMONARY HYPERTENSION and it is now rarely used.
References in periodicals archive ?
10) Historically, the limitations have been due to a variety of concerns these include valvulopathy associated with fenfluramine and dexfenfluramine, the abuse potential and psychiatric side effects associated with rimonabant, and, most recently, cardiac adverse events associated with sibutramine.
One component of that medication, fenfluramine, was taken off the market; the other, phentermine (now a component of Qnexa) is generally considered safe at low doses.
To the best of our knowledge, the concern with the heart valves was limited to fenfluramine and dexfenfluramine," two fen-phen ingredients that were banned from the market in 1997, said Colman, who started in his division 15 years ago as risks from the treatment were emerging.
3 Drug-and toxin-induced PAH, caused by certain drugs and toxins including aminorex, fenfluramine, dexfenfluramine, and toxic rapeseed oil have been associated with the development of PAH.
Previously, severe heart valve disorders have been reported in patients receiving a combination of the anorectic drugs such as fenfluramine and phentermine (8, 9).
Vascular heart disease associated with fenfluramine phentermine.
Now, the researchers have defined a circuit in the brain that explains the ways fenfluramine, a component of Fen-phen, suppresses appetite.
While being told that their sons would undergo only a safe test to discover if they might have any medical problems, the children were instead subjected to doses of the drug fenfluramine (one of the components of the banned drug Fen-Phen).
Wyeth marketed the dangerous "fen" half of it--the drugs fenfluramine and dexfenfluramine, sold under the brand names Pondimin and Redux.
Ironically, the FDAMA was enacted only two months after the popular diet drugs fenfluramine and dexfenfluramine were withdrawn from the market because of adverse events linked to their off-label use.
The objective of the analysis presented in this article is to examine the public disclosure of serious side effects associated with the combined use of fenfluramine and phentermine, also known as fen-phen, a prescription weight loss drug cocktail produced and actively promoted by Robins Pharmaceuticals and Wyeth-Ayerst, both divisions of American Home Products.
In addition, certain medications, particularly diet pills such as Fen-Phen (a combination of fenfluramine and phentermine that was taken off the market several years ago) may cause this condition.