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fenfluramine

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fenfluramine /fen·flur·amine/ (fen-flldbomacr´ah-mēn) an amphetamine derivative, formerly used as an anorectic in the form of the hydrochloride salt.
fen·flu·ra·mine (fn-flr-mn)
n.
A fluorinated compound that is used in the treatment of refractory obesity.

fenfluramine [fen-flo̳r´ah-mēn]
an appetite suppressant used as the hydrochloride salt; unlike the amphetamines, it seems to depress rather than stimulate the central nervous system.

fenfluramine
Pondimin®, Redux® Internal medicine An adrenergic appetite suppressing–anorectic amphetamine congener, which, unlike amphetamine, depresses the CNS; fenfluramine ↑ serotonin levels and imparts a sensation of fullness from a lower intake of food and was prescribed as a short-term adjunct in obesity; it was withdrawn from the market following its association with heart valve abnormalities and other cardiac complications Adverse effects Pulmonary HTN, attributed either to serotonic vasoconstriction or altered depolarization of pulmonary vascular smooth muscle membrane. See Fen/Phen.


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An example of this is the Fen-Phen cocktail, a mixture of phentermine and fenfluramine.
Conventional wisdom is that fenfluramine increases serotonin release that then activates serotonin receptors in the brain to regulate food intake and body weight, but unfortunately, this drug also causes lesions in heart valves," he said.
In addition, certain medications, particularly diet pills such as Fen-Phen (a combination of fenfluramine and phentermine that was taken off the market several years ago) may cause this condition.
 
 
 
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