2-1 mg/kg 5-15 mg/kg (oral) Oxcarbazepine 10 mg/kg 30-60 mg/kg (oral) Levetiracetam 10 mg/kg 40-80 mg/kg (oral, iv) Phenytoin 5 mg/kg 5-10 mg/kg (oral, iv) Felbamate
(oral) 15 mg/kg 45-60 mg/kg Drug (Route of Administration) Comments Vigabatrin (oral) First-line therapy for infantile spasms.
The odds ratio was under 1 for carbamazepine, which had the second fewest patients in studies; and for divalproex; an odds ratio for felbamate
could not be calculated because there were not many patients in the trials and there were no suicidality events among patients on placebo or the drug.
oral suspension is shipping and available through wholesalers-distributors as well as directly to the trade.
Phenytoin increases blood levels of felbamate
, oxcarbazepine, and topiramate
is "an anticonvulsant that produces profound apathy," Dr.
Amneal Pharmaceuticals, LLC is pleased to announce that its generic Felbamate
tablets are now available in 400 mg and 600 mg strengths.
Through the NINDS antiepileptic drug discovery program that he led for decades, a number of important new therapies were added to the armamentarium, including felbamate
, topiramate, lacosamide and rufinamide, as well as the newest AED ezogabine.
It is not known whether this change in serum levels increases ovulation, but caution is appropriate for patients taking phenytoin, barbiturates, carbamazepine, topiramate, felbamate
, and vigabatrin.
Lamotrigine (Lamictal), topiramate (Topamax), or felbamate
(Felbatol) provide alternatives to valproate (Depacon) or benzodiazepines for broad-spectrum treatment of primary generalized seizures and partial-onset seizures.
5 [micro]g/L trans-10,11-Dihydroxycarbamazepine (a) 5 mg/L Disopyramide 6 mg/L Doxepin (a) 500 [micro]g/L Estradiol 1 [micro]g/L Estriol 267 [micro]g/L Ethosuximide 120 mg/L 2-Ethyl-2-phenylmalonamide (a) 5 mg/L Felbamate
(a) 250 mg/L Ferritin 670 [micro]g/L Folate 13 [micro]g/L Follicle-stimulating hormone (FSH) 70 IU/L Free [T.
Table 1: Seizure medicines that may interfere with hormonal birth control Generic Name Brand Name * Carbamazepine Tegretol, Tegretol XR, Carbatrol Felbamate
Felbatol Lamotrigine Lamictal Oxcarbazepine Trileptal Phenobarbital Luminal Phenytoin Dilantin, Phenytek Primidone Mysoline Topiramate Topamax * Medicines may be known by different brand names in different countries.
The human pregnancy experience is too limited to assess the embryo/fetal risk for the other second-generation agents: felbamate
(Felbatol), gabapentin (Neurontin), pregabalin (Lyrica), levetiracetam (Keppra), tiagabine (Gabitril), and topiramate (Topamax).