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feedback inhibition

   Also found in: Dictionary/thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
feedback inhibition
n.
An inhibition of activity due to the production of an end product of the action. Also called feedback mechanism.

inhibition
arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.


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PIK3CA, AKT1 mutation and HER2 amplification gene signatures (GS) suggest predominantly negative feedback inhibition of PI3K/AKT pathway in human breast cancer (BC).
The most viable of these include the Error Catastrophe Theory, related to faulty molecular transcription and errors in cellular function, the Crosslinkage Theory, in which progressively increasing cross-linking between proteins slows the body functions down, and the Neuroendocrine Theory, in which changes in homeostasis and hormone levels occur through time due to an increasing loss of sensitivity of receptors to feedback inhibition.
Androgenic phytonutrients from herbs (such as Tribulus terrestris, Muira puama, Avena sativa and nettle leaf), amino acids (including L-arginine) and certain foods such as melons naturally increase testosterone production without the danger of negative feedback inhibition as experienced with anabolic steroids and other hormones.
 
 
 
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