A new hypothesis has been espoused about the initial rapid febrile response to an endotoxin involving the vagus nerve.
Support for the antipyretic properties of AVP has been documented by an enhanced febrile response following AVP blockade.
In rats infused with IL-1 into the lateral cerebral ventricle to induce fever, pretreatment with an AVP V1 antagonist into the VSA enhanced the magnitude and duration of the febrile response (Cooper et al.
Following administration of endotoxin, endogenous pyrogens, or prostaglandin, the febrile response in Brattleboro rats was not enhanced (Eagan, Kasting, Veale, & Cooper, 1982; Ruwe, Veale, & Cooper, 1988).
In a similar study (Kasting, 1986), hemorrhage of 20% blood volume in rats also reduced the febrile response to E.
Drug resistance could not account for this finding: 46% of patients infected with a fully susceptible Beijing strain compared with 19% of patients infected with susceptible non-Beijing strains had a febrile response (p-0.
Forty-eight percent of the patients infected with Beijing strains and 21% of the patients infected with other strains had a transient febrile response shortly after start of treatment.
Ryan Vander Veen, added, "In our research studies with pigs, we have been inserting the LifeChips subcutaneously near the base of the ear in order to monitor temperature and look for a febrile response
following a disease challenge.
Mycobacterium tuberculosis Beijing genotype strains associated with febrile response to treatment.
For instance, in Jakarta, Indonesia, tuberculosis patients infected with Beijing genotype strains were significantly more likely to have febrile responses during the first 2 weeks of treatment (5).