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feathery degenerationA descriptive term for the changes in cytoplasm of hepatocytes caused by chronic cholestasis secondary to extrahepatic biliary destruction and in bile infarcts; the “feathers” correspond to phospholipids and bile acid crystals, which may be accompanied by an intracellular triad consisting of hydropic swelling, aggregation and reticulation of bile pigment and feathery cytoplasm, due to the toxic effect of bile salts.
deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form. When there is chemical change of the tissue itself it is true degeneration; when the change consists in the deposit of abnormal matter in the tissues, it is infiltration. See also wallerian degeneration, Zenker's necrosis.
cloudy swelling, an early stage of degenerative change characterized by swollen, parboiled-appearing tissues which revert to normal when the cause is removed.
swelling of the cytoplasm in epidermal cells without vacuolization, enlarged or condensed nuclei and acantholysis. A characteristic of viral infections of the skin. Called also koilocytosis.
degeneration with conversion of the tissues into a gelatinous or gumlike material.
degeneration with formation of cysts.
deposit of fat globules in a tissue.
said of hepatocytes; a hydropic change in hepatocytes which have suffered long-term exposure to cholestasis.
deposition or replacement with eosinophilic fibrillar or granular substance resembling fibrin.
degeneration into fibrous tissue.
a regressive change in cells in which the cytoplasm takes on a homogeneous, glassy appearance; also used loosely to describe the histological appearance of tissues. Called also hyalinosis.
see hydropic degeneration.
degenerative changes in the macula retinae.
degeneration with increased mucin which can be epithelial or mesenchymal in origin.
degeneration with accumulation of mucus in epithelial tissues. Called also myxomatous degeneration.
see mucous degeneration (above).
extreme intracellular edema of epidermal cells, resulting in rupture and multilocular intraepidermal vesicles with septae formed by the remaining cell walls. Seen in acute inflammatory dermatoses.
on microscopic examination has the physical appearance of a sponge. Usually applied to tissue of the central nervous system, caused by the loss of myelin.