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favism

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favism /fa·vism/ (fa´vizm) an acute hemolytic anemia precipitated by fava beans (ingestion, or inhalation of pollen), usually caused by deficiency of glucose-6-phosphate dehydrogenase in the erythrocytes.
fa·vism (fvzm)
n.
An acute hereditary condition in which the ingestion of certain species of beans, or the inhalation of the pollen of their flowers, causes fever, headache, abdominal pain, severe anemia, prostration, and coma.

favism
[fā′vizəm]
Etymology: It, fava, bean
an acute hemolytic anemia caused by ingestion of the beans or inhalation of the pollen from the Vicia faba (fava) plant. Sensitive individuals have a genetic deficiency of glucose-6-phosphate dehydrogenase, usually the result of a hereditary biochemical abnormality of the erythrocytes. Symptoms include dizziness, headache, vomiting, fever, jaundice, eosinophilia, and often diarrhea. The condition occurs primarily in persons of southern Italian extraction and is treated by blood transfusion and avoidance of fava beans and pollen. See also glucose-6-phosphate dehydrogenase deficiency.


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Additional factors affecting digestibility of various legumes include: saponins, protease inhibitors, lathyrogens, phytohaemagglutinins, favism, and cyanogenic glucosides as reported by Gupta (1987).
In the following chapters, we travel to Sardinia where favism is still evident today (glucose-6-phosphate dehydrogenase deficiency) and discover why the 'disease' became a buffer against malaria.
Favism The advice of Greek philosopher of Pythagoras to avoid fava beans was prescient, as later scientists discovered a genetic deficiency that causes acute hemolytic anemia in certain people who consume the legumes.
 
 
 
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