fatty liver of pregnancy


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Acute Fatty Liver of Pregnancy

A rare (1:10,000–15,000) idiopathic complication of pregnancy, most often affecting primiparas with male infants or twins, variably associated with pre-eclampsia.
Clinical findings Onset after 35th week—occasionally as early as the 13th week—possibly progressing to fulminant hepatic failure with jaundice, encephalopathy, DIC, death.
Prognosis ±20% mortality
Management Terminate pregnancy

fatty liver of pregnancy

Acute fatty liver of pregnancy A rare idiopathic complication of pregnancy, most often affecting primiparas with ♂ infants or twins, ± associated with pre-eclampsia Clinical Onset after 35th wk–occasionally by the 13th wk–caveat medicus, possibly progressing to fulminant hepatic failure with jaundice, encephalopathy, DIC, death Management Terminate pregnancy Prognosis ±20% death. See MTP complex.
References in periodicals archive ?
The differential diagnoses of intra hepatic infarction include intrahepatic abscess, acute fatty liver of pregnancy, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, ruptured hepatic adenoma, hepatocellular carcinoma and hemangioma.
The most common causes of acute pancreatitis in pregnancy are: gallstones (66%), alcohol abuse (12%), idiopathic (17%),hyperlipidemia (4%), and less commonly hyperparathyroidism, trauma, medication and fatty liver of pregnancy [17].
Other causes of acute liver failure not induced by acetaminophen overdose include hepatitis B disease, autoimmune hepatitis, Wilson disease, fatty liver of pregnancy, and HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome.
Previous SMRs have not identified cases of acute fatty liver of pregnancy (AFLP), but there is an impression that this condition does occasionally occur.
Five conditions that can lead to pregnancy-related deaths were considered in the analyses of severe maternal morbidity: acute fatty liver of pregnancy (a buildup of fat in the liver), amniotic fluid embolism (the presence of amniotic fluid, fetal cells or other debris in the woman's circulatory system), pulmonary embolism, eclampsia (characterized by convulsions during pregnancy or the first 10 days after delivery, followed by specified clinical events) or hysterectomy at the time of delivery.
A group of Singleton Hospital consultants have developed a new way to diagnose acute fatty liver of pregnancy (AFLP), based on clinical symptoms and signs, and simple laboratory investigations.
Acute fatty liver of pregnancy can be seen with low platelet counts and hemolysis.
The study's findings could also lead to a better understanding of potential links between fetuses that do not properly oxidize fatty acids and mothers with pre-eclampsia, acute fatty liver of pregnancy (a life-threatening complication that often appears in the third trimester), and the HELLP syndrome (hemolysis, elevated liver function and low platelets).
WASHINGTON -- Acute fatty liver of pregnancy must be ruled out in any woman who presents in the third trimester with nausea, vomiting, epigastric pain, or malaise, Michael F.
shock), gastric volvulus, gastric-outlet obstruction, pancreatitis, cancer, acute fatty liver of pregnancy, overwhelming infection, severe hypothermia, severe emesis, herpes infection, nasogastric-tube trauma, and hyperglycemia (particularly in diabetic ketoacidosis).
Thrombocytopenia and microangiopathic hemolytic anemia are more severe in HELLP syndrome than in preeclampsia, and acute fatty liver of pregnancy manifests itself primarily as severe liver damage.