fatty liver of pregnancy

Acute Fatty Liver of Pregnancy

A rare (1:10,000–15,000) idiopathic complication of pregnancy, most often affecting primiparas with male infants or twins, variably associated with pre-eclampsia.
Clinical findings Onset after 35th week—occasionally as early as the 13th week—possibly progressing to fulminant hepatic failure with jaundice, encephalopathy, DIC, death.
Prognosis ±20% mortality
Management Terminate pregnancy

fatty liver of pregnancy

Acute fatty liver of pregnancy A rare idiopathic complication of pregnancy, most often affecting primiparas with ♂ infants or twins, ± associated with pre-eclampsia Clinical Onset after 35th wk–occasionally by the 13th wk–caveat medicus, possibly progressing to fulminant hepatic failure with jaundice, encephalopathy, DIC, death Management Terminate pregnancy Prognosis ±20% death. See MTP complex.
References in periodicals archive ?
Acute fatty liver of pregnancy (AFLP) is an uncommon potentially fatal disorder.
Liver problems that women may have in pregnancy are preeclampsia, eclampsia, acute fatty liver of pregnancy, haemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, and viral infections like hepatitis A, B, C, E, drug-induced hepatitis, connective tissue disorders, systemic lupus erythmatosis (SLE), auto-immune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, Wilson's disease and Epstein-Bar virus infection.
Study of the liver changes occurring in preeclampsia and their possible pathogenetic connection with acute fatty liver of pregnancy.
The differential diagnoses of intra hepatic infarction include intrahepatic abscess, acute fatty liver of pregnancy, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, ruptured hepatic adenoma, hepatocellular carcinoma and hemangioma.
The most common causes of acute pancreatitis in pregnancy are: gallstones (66%), alcohol abuse (12%), idiopathic (17%),hyperlipidemia (4%), and less commonly hyperparathyroidism, trauma, medication and fatty liver of pregnancy [17].
Previous SMRs have not identified cases of acute fatty liver of pregnancy (AFLP), but there is an impression that this condition does occasionally occur.
Pathophysiologic abnormalities in many of these disorders include hemolytic anemia, thrombotic microangiopathy, acute fatty liver of pregnancy, and lupus exacerbation (Sibai, 2007).
Five conditions that can lead to pregnancy-related deaths were considered in the analyses of severe maternal morbidity: acute fatty liver of pregnancy (a buildup of fat in the liver), amniotic fluid embolism (the presence of amniotic fluid, fetal cells or other debris in the woman's circulatory system), pulmonary embolism, eclampsia (characterized by convulsions during pregnancy or the first 10 days after delivery, followed by specified clinical events) or hysterectomy at the time of delivery.
A group of Singleton Hospital consultants have developed a new way to diagnose acute fatty liver of pregnancy (AFLP), based on clinical symptoms and signs, and simple laboratory investigations.
Acute fatty liver of pregnancy can be seen with low platelet counts and hemolysis.
WASHINGTON -- Acute fatty liver of pregnancy must be ruled out in any woman who presents in the third trimester with nausea, vomiting, epigastric pain, or malaise, Michael F.